ID   UL298_HCMVA             Reviewed;         701 AA.
AC   C0H677;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Protein UL29/UL28;
GN   Name=UL29;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AD169 varUK;
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9371656; DOI=10.1128/jvi.71.12.9833-9836.1997;
RA   Dargan D.J., Jamieson F.E., Maclean J., Dolan A., Addison C., McGeoch D.J.;
RT   "The published DNA sequence of human cytomegalovirus strain AD169 lacks 929
RT   base pairs of DNA affecting genes UL42 and UL43.";
RL   J. Virol. 71:9833-9836(1997).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19625400; DOI=10.1128/jvi.00396-09;
RA   Mitchell D.P., Savaryn J.P., Moorman N.J., Shenk T., Terhune S.S.;
RT   "Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced
RT   mRNA and stimulate accumulation of immediate-early RNAs.";
RL   J. Virol. 83:10187-10197(2009).
RN   [5]
RP   INTERACTION WITH UL38; HOST HDAC1 AND HOST MTA2.
RX   PubMed=20585571; DOI=10.1371/journal.ppat.1000965;
RA   Terhune S.S., Moorman N.J., Cristea I.M., Savaryn J.P., Cuevas-Bennett C.,
RA   Rout M.P., Chait B.T., Shenk T.;
RT   "Human cytomegalovirus UL29/28 protein interacts with components of the
RT   NuRD complex which promote accumulation of immediate-early RNA.";
RL   PLoS Pathog. 6:E1000965-E1000965(2010).
CC   -!- FUNCTION: Contributes to activation of immediate-early gene expression.
CC       {ECO:0000269|PubMed:19625400}.
CC   -!- SUBUNIT: Interacts with UL38 and host HDAC1; these interactions are
CC       necessary for the HDAC1 interaction with UL38. Interacts with host
CC       MTA2. {ECO:0000269|PubMed:20585571}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:19625400}. Host
CC       nucleus {ECO:0000269|PubMed:19625400}. Host cytoplasm
CC       {ECO:0000269|PubMed:19625400}. Note=Expressed exclusively within the
CC       host nucleus in early times of infection and then present in both
CC       nucleus and cytoplasm at 72 hours post infection.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BK000394; DAA06451.1; -; Genomic_DNA.
DR   PRIDE; C0H677; -.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 3.
PE   1: Evidence at protein level;
KW   Early protein; Host cytoplasm; Host nucleus; Virion.
FT   CHAIN           1..701
FT                   /note="Protein UL29/UL28"
FT                   /id="PRO_0000417859"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   701 AA;  79053 MW;  FEBD647AA1B60F38 CRC64;
     MSGRRKGCSA ATASSSSSSP PSRLPPLPGH ARRPRRKRCL VPEVFCTRDL ADLCVRRDYE
     GLRRYLRRFE GSCVSLGWPS QCIYVVGGEH SPHSLTEIDL EHCQNDFFGE FRALHLIGTV
     SHATCRYQVF VDAYGAVFAY DAQEDCLYEL ASDLAGFFAK GMIRCDPVHE SICARLQPNV
     PLVHPDHRAE LCRRSRASAR GRYLRSLLAF RELLACEDTA ARCAYVEAHR EAQLTLIWPE
     KHSLVLRTAR DLGLSASMLR RFQRSLYTRE PVMPLGEIEG AEDKTFFHRV RILCGDTGTV
     YAALVGQDKL VRLARDLRGF VRVGLALLID DFRYESIGPV DRSSLYEANP ELRLPFKKRR
     LVVGYFDSLS SLYLRGQPKF SSIWRGLRDA WTHKRPKPRE RASGVHLQRY VRATAGRWLP
     LCWPPLHGIM LGDTQYFGVV RDHKTYRRFS CLRQAGRLYF IGLVSVYECV PDANTAPEIW
     VSGHGHAFAY LPGEDKVYVL GLSFGEFFEN GLFAVYSFFE RDYVDEIVEG AWFKHTFAGM
     YELSQILHDR ANLLRVCQLH AGSKIRLGGS PACTFTFGSW NVAEADEANN FVIGVLEQAH
     FVVIGWMEPV NKAVFMDAHG GIHVLLYGTM LVKLAETLRG FIRQGSFWFR CPRRFCFSPL
     DSSATVAAKP VSSHTSPAYD VSEYVFSGRS VLDSVSGTGA S