ID   UL298_HCMVM             Reviewed;         700 AA.
AC   Q6SWA3; D2K3J7;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   23-FEB-2022, entry version 57.
DE   RecName: Full=Protein UL29/28;
GN   Name=UL29;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Contributes to activation of immediate-early gene expression.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with UL38 and host HDAC1; these interactions are
CC       necessary for the HDAC1 interaction with UL38. Interacts with host MTA2
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Host cytoplasm {ECO:0000250}. Note=Expressed exclusively within the
CC       host nucleus in early times of infection and then present in both
CC       nucleus and cytoplasm at 72 hours post infection. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY446894; AAR31593.2; -; Genomic_DNA.
DR   RefSeq; YP_081487.2; NC_006273.2.
DR   PRIDE; Q6SWA3; -.
DR   GeneID; 3077519; -.
DR   KEGG; vg:3077519; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 3.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..700
FT                   /note="Protein UL29/28"
FT                   /id="PRO_0000417860"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   700 AA;  78971 MW;  845708E2851DDA72 CRC64;
     MSGRRKGCSA ATASSSSSSP PSRLPLPGHA RRPRRKRCLV PEVFCTRDLA DLCVRRDYEG
     LRRYLRRFEG SCVSLGWPSQ CIYVVGGEHS PHSLTEIDLE HCQNDFFGEF RALHLIGTVS
     HATCRYQVFV DAYGAVFAYD AQEDCLYELA SDLAGFFAKG MIRCDPVHES ICARLQPNVP
     LVHPDHRAEL CRRSRASARG RYLRSLLAFR ELLACEDTAA RCAYVEAHRE AQLTLIWPEK
     HSLVLRTARD LGLSASMLRR FQRSLYTREP VMPLGEIEGA EDKTFFHRVR ILCGDTGTVY
     AALVGQDKLV RLSRDLRGFV RVGLALLIDD FRYESIGPVD RSSLYEANPE LRLPFKKRRL
     VVGYFDSLSS LYLRGQPKFS SIWRGLRDAW THKRPKPRER ASGVHLQRYV RATAGRWLPL
     CWPPLHGIML GDTQYFGVVR DHKTYRRFSC LRQAGRLYFI GLVSVYECVP DANTAPEIWV
     SGHGHAFAYL PGEDKVYVLG LSFGEFFENG LFAVYSFFER DYVDEIVEGA WFKHTFAGMY
     ELSQILHDRA NLLRVCQLHA GSKIRLGGSP ACTFTFGSWN VAEADEANNF VIGVLEQAHF
     VVIGWMEPVN KAVFMDAHGG IHVLLYGTML VKLAETLRGF IRQGSFWFRC PRRFCFSPLD
     SSATVAAKPV SSHTSPAYDV SEYVFSGRSV LDSVSGTGAS