ID   UL31_HCMVA              Reviewed;         595 AA.
AC   P16848; Q7M6Q2;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   02-JUN-2021, entry version 53.
DE   RecName: Full=Protein UL31 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=UL31 {ECO:0000303|PubMed:29937271};
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   FUNCTION, INTERACTION WITH HOST CGAS, AND SUBCELLULAR LOCATION.
RX   PubMed=29937271; DOI=10.1016/j.chom.2018.05.007;
RA   Huang Z.F., Zou H.M., Liao B.W., Zhang H.Y., Yang Y., Fu Y.Z., Wang S.Y.,
RA   Luo M.H., Wang Y.Y.;
RT   "Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate
RT   Immune Evasion.";
RL   Cell Host Microbe 24:69-80(2018).
CC   -!- FUNCTION: Plays a role in the inhibition of host innate immune system
CC       by targeting host CGAS and promoting dissociation of DNA from CGAS,
CC       thereby inhibiting the enzymatic activity of CGAS.
CC       {ECO:0000269|PubMed:29937271}.
CC   -!- SUBUNIT: Interacts with host CGAS. {ECO:0000269|PubMed:29937271}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:29937271}.
CC       Host nucleus {ECO:0000269|PubMed:29937271}.
CC   -!- SIMILARITY: Belongs to the herpesviridae U10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA35430.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X17403; CAA35430.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK000394; DAA00136.1; -; Genomic_DNA.
DR   PIR; S09794; S09794.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IDA:UniProtKB.
DR   InterPro; IPR007578; Herpes_U10.
DR   Pfam; PF04489; DUF570; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Signal; Viral immunoevasion.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..595
FT                   /note="Protein UL31"
FT                   /id="PRO_0000038314"
FT   REGION          47..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   595 AA;  65748 MW;  8E252FA818E6F715 CRC64;
     MGDKPTLVTL LTVAVSSPPP SSPLPLVSFT ELLLPPPSVA AAAVAATATS EVGEKTAEQE
     VAAADPETGN ERRENRENEG GETRTTGTTA VKRSHDGIPR QLAERLRLCR HMDPEQDYRL
     PAQDVVTSWI EALRDADRDN YGRCVRHAKI HRSASHLTAY ESYLVSITEQ YNTASNVTEK
     ASYVQGCIFL SFPVIYNNTQ GCGYKYDWSN VVTPKAAYAE LFFLLCSTSE SSVVLQPLIT
     KGGLCSSMAV YDEETMRQSQ AVQIGFLHTQ LVMVPFVPHA CPHYAVPFTT PGKPGCGGAP
     SGVAGLEEAA PFGRVSVTRH GATLLCRVDH LTWISKRVTT YGHKKITRYL AQFRGTMDDD
     EAALPGEDEA WIASKNVQYE FMGLIFTVNV DSLCVDAEQR QLLGTVATSF CHRVSDKITA
     RNMPRAFSFY LLTSAQRGYD LRFSRNPSLF FSGDALNCPL LNEPNVFSLT VHAPYDIHFG
     VQPRQTVELD LRYVQITDRC FLVANLPHED AFYTGLSVWR GGEPLKVTLW TRTRSIVIPQ
     GTPIATLYQI TEGDGNVYSY NHHTVFRQMH AAGTTTFFLG DMQLPADNFL TSPHP