ID   UL31_HCMVM              Reviewed;         595 AA.
AC   Q6SWA0; D2K3J9;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 46.
DE   RecName: Full=Protein UL31 {ECO:0000250|UniProtKB:P16848};
DE   Flags: Precursor;
GN   Name=UL31;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the inhibition of host innate immune system
CC       by targeting host CGAS and promoting dissociation of DNA from CGAS,
CC       thereby inhibiting the enzymatic activity of CGAS.
CC       {ECO:0000250|UniProtKB:P16848}.
CC   -!- SUBUNIT: Interacts with host CGAS. {ECO:0000250|UniProtKB:P16848}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P16848}.
CC       Host nucleus {ECO:0000250|UniProtKB:P16848}.
CC   -!- SIMILARITY: Belongs to the herpesviridae U10 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31596.1; -; Genomic_DNA.
DR   RefSeq; YP_081490.1; NC_006273.2.
DR   PRIDE; Q6SWA0; -.
DR   DNASU; 3077508; -.
DR   GeneID; 3077508; -.
DR   KEGG; vg:3077508; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR007578; Herpes_U10.
DR   Pfam; PF04489; DUF570; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Inhibition of host innate immune response by virus; Reference proteome;
KW   Signal; Viral immunoevasion.
FT   SIGNAL          1..40
FT                   /evidence="ECO:0000255"
FT   CHAIN           41..595
FT                   /note="Protein UL31"
FT                   /id="PRO_0000418283"
FT   REGION          47..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   595 AA;  65790 MW;  324423FBC2158808 CRC64;
     MGDKPTLVTL LTVAVSSPPP SSPLPLVSFT ELLLPPPSVA AAAVAATATS EVGEKTAEQE
     VAAAGPETRN ERRENREDEG GETRTTGTTA VKRSHDGIPR QLAERLRLCR HMDPEQDYRL
     PAQDVVTSWI EALRDADRDN YGRCVRHAKI HRSASHLTAY ESYLVSITEQ YNTASNVTEK
     ASYVQGCIFL SFPVIYNNTQ GCGYKYDWSN VVTPKAAYAE LFFLLCSTSE SSVVLQPLIT
     KGGLCSSMAV YDEETMRQSQ AVQIGFLHTQ LVMVPFVPHA CPHYAVPFTT PGKPGCGGAP
     SGVAGLEETA PFGRVSVTRH GATLLCRVDH LTWISKRVTT YGHKKITRYL AQFRGTMDDD
     EAALPGEDEA WIASKNVQYE FMGLIFTVNV DSLCVDAEQR QLLGTVATSF CHRVSDKITA
     RNMPRAFSFY LLTSAQRGYD LRFSRNPSLF FSGDALNCPL LNEPNVFSLT VHAPYDIHFG
     VQPRQTVELD LRYVQITDRC FLVANLPHED AFYTGLSVWR GGEPLKVTLW TRTRSIVIPQ
     GTPIATLYQI TEGDGNVYSY NHHTVFRQMH AAGATTFFLG DMQLPADNFL TSPHP