UL32_EHV1A
ID UL32_EHV1A Reviewed; 620 AA.
AC P68338; P28952; Q6S6P3;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Packaging protein UL32 homolog;
DE AltName: Full=Glycoprotein 300;
DE Short=GP300;
OS Equine herpesvirus 1 (strain AB1) (EHV-1) (Equine abortion virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10328;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND IDENTIFICATION OF PROTEIN.
RX PubMed=1331295; DOI=10.1099/0022-1317-73-11-2933;
RA Whittaker G.R., Bonass W.A., Elton D.M., Halliburton I.W., Killington R.A.,
RA Meredith D.M.;
RT "Glycoprotein 300 is encoded by gene 28 of equine herpesvirus type 1: a new
RT family of herpesvirus membrane proteins?";
RL J. Gen. Virol. 73:2933-2940(1992).
CC -!- FUNCTION: Plays a role in efficient localization of neo-synthesized
CC capsids to nuclear replication compartments, thereby controlling
CC cleavage and packaging of virus genomic DNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Note=Mainly
CC cytoplasmic in transfected cell culture. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the herpesviridae UL32 protein family.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally [PubMed:1331295] thought to be an envelope
CC glycoprotein. {ECO:0000305}.
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DR EMBL; M84239; AAA46094.1; -; Genomic_DNA.
DR PIR; B36798; WZBEC1.
DR RefSeq; YP_053073.1; NC_001491.2.
DR SMR; P68338; -.
DR PRIDE; P68338; -.
DR GeneID; 1487568; -.
DR KEGG; vg:1487568; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR002597; Herpes_env.
DR Pfam; PF01673; Herpes_env; 1.
DR PROSITE; PS51988; HERPESVIRUS_UL32; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; Metal-binding; Zinc; Zinc-finger.
FT CHAIN 1..620
FT /note="Packaging protein UL32 homolog"
FT /id="PRO_0000116015"
FT REGION 100..186
FT /note="Zinc finger 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT REGION 306..605
FT /note="Zinc finger 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT REGION 433..525
FT /note="Zinc finger 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 100
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 103
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 180
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 186
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 306
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 307
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 433
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 436
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 518
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 525
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 568
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT BINDING 605
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
SQ SEQUENCE 620 AA; 67301 MW; C475E85B2EA1C667 CRC64;
MAASCNLDVI GEDGGCALTG GWQPGAFERP YMGFDARLLS TNSSLCSELI FSAHLMQISP
TPQPREQVDV CEDPDNDPPE PSCAQFVDAV ADSLALDKLC LICRTIDLYR RQFGLSPQWI
ADYAMLCTKT LAAPPCAVAT VVAAFEFVYL MDKHYLRRGK TTLVGAFARR VLTLVDIQRH
FFLHVCFRTD GGVPRCAASG TAPAATAMAG LGMADKVQYS NYSFLVQSST RAMLLTVADV
PSGDDGALQA VPHGRHGAGR PADGGGGVFG PKQQSTVAAL MSWKECAKMI DCSGSERRRP
GATMTCCERA RADDDEYERQ LLSTENTYLG SADNQAEGGN DTHLKWGYAD LTLLLLSQSS
TWEASEKTSL ASQSRRACVE EYWASHRTVL ARDTAPRFAR FVDADAVPDT ATGPVLATTL
KHVRSRGRTC AECVLCNLIL TREHWLALRR FKRDVISYSS NNANLFDCIS PVLSALSDAN
SEPLAGDCGV GGGGTCPEDS GRFLELMHAA GTEAIYKHLF CDPMCALVEL QTNPSVLFSP
IGPPPEPDEI ELQKARLASE NWFSGRVCAG LWALAFTFKT YQIFTPKPTA CAAFIKDAGL
LLRRHNLPLI SLEHTLCNYV
