ID   UL32_HHV6Z              Reviewed;         484 AA.
AC   Q9QJ33;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Packaging protein UL32 homolog;
GN   Name=U36;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z29;
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Plays a role in efficient localization of neo-synthesized
CC       capsids to nuclear replication compartments, thereby controlling
CC       cleavage and packaging of virus genomic DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Note=Mainly
CC       cytoplasmic in transfected cell culture. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL32 protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF157706; AAD49650.1; -; Genomic_DNA.
DR   RefSeq; NP_050217.1; NC_000898.1.
DR   SMR; Q9QJ33; -.
DR   PRIDE; Q9QJ33; -.
DR   DNASU; 1497038; -.
DR   GeneID; 1497038; -.
DR   KEGG; vg:1497038; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002597; Herpes_env.
DR   Pfam; PF01673; Herpes_env; 2.
DR   PROSITE; PS51988; HERPESVIRUS_UL32; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..484
FT                   /note="Packaging protein UL32 homolog"
FT                   /id="PRO_0000408436"
FT   REGION          74..154
FT                   /note="Zinc finger 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   REGION          286..390
FT                   /note="Zinc finger 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         74
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         77
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         148
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         154
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         286
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         289
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         383
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         390
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
SQ   SEQUENCE   484 AA;  56379 MW;  24C06E5251A3FF55 CRC64;
     MYKGWDSEAL SIQSEIVNEI LLYCYLTPQP PIPSETTTAT SPTNIENEIS NLESSENLEE
     LKRLSVALNI DRRCNICSIV NLCLKQNKSW IYDYSLLCYK CNYAPKTPLS LLIVSAEFIM
     LIRERFPNIN FDGLFQNNIV SIFDFHVHFF IHRCFANTVN DHIQSENITL NHMAIIRSTL
     LKEDSIPHIK IKKFLTKKMN PKKTQSPELN KKLTVPMKTR FTTLLFYMWS GTNVFDRVPF
     TDLTIRKHRF IKNLYSNKTD IELTAGPILL AQIPFSITKN KTTSVCLLCE LMAASKQDYL
     FLKYLHQSIM DYCQNNLKMI DRVQFVIADI FEKTKIHMHV KNLSDYSKAI FDNEFSFSDD
     NFTLDTHVYL ILRQTGTVGV YKHFFCDPLC LANCKTINPE VLFNTTDAGE IQDLKVTICY
     RNEYLSIVEK HVWLAIHLFK AFQIIKPNHK NKTQIAEFLK DFTNLLALHH FDIVDPIFTV
     NYYV