ID   UL32_HHV7J              Reviewed;         485 AA.
AC   P52464;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Packaging protein UL32;
GN   Name=U36;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Plays a role in efficient localization of neo-synthesized
CC       capsids to nuclear replication compartments, thereby controlling
CC       cleavage and packaging of virus genomic DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Note=Mainly
CC       cytoplasmic in transfected cell culture. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL32 protein family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be an envelope glycoprotein.
CC       {ECO:0000305}.
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DR   EMBL; U43400; AAC54698.1; -; Genomic_DNA.
DR   PIR; T41938; T41938.
DR   RefSeq; YP_073776.1; NC_001716.2.
DR   SMR; P52464; -.
DR   DNASU; 3289494; -.
DR   GeneID; 3289494; -.
DR   KEGG; vg:3289494; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002597; Herpes_env.
DR   Pfam; PF01673; Herpes_env; 2.
DR   PROSITE; PS51988; HERPESVIRUS_UL32; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..485
FT                   /note="Packaging protein UL32"
FT                   /id="PRO_0000116018"
FT   REGION          73..155
FT                   /note="Zinc finger 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   REGION          287..391
FT                   /note="Zinc finger 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         73
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         76
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         149
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         155
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         287
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         290
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         384
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         391
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
SQ   SEQUENCE   485 AA;  55974 MW;  F5FEF60DE2BE0A9F CRC64;
     MAYKGWNSDS FSMNSELFNE ILLYAHLDSS GIDSDDLNTN PNTLENEINS VEKTLNIEEL
     KKITTALNID NRCNICSIIN ICLRHETDKM WIYDYALLCY KCNAAPRTPL AVVIIATEFM
     QLIQKHFLNI NFDGLFLNNI LSILDFHVHF FINRCFSNTN DDLLHNENIT LYHMAILKSL
     LLEDESIPNI RIKKFKLKGK PTKKQHGNAI LEKQTLPLNT HFTHLIFYMW AGTNIFDRIS
     LTDLAIKKRQ ILKAIYSTKN ELNCSAGPIL LSQIPISITK NATSSVCLLC ELMTSSQKNF
     DLLQFIYTSV INYCQNNLKM IDRIQFVLAN LLDLARIYTN VKTTSDCSKI VLANEQEFSN
     SDFVIDCHSF LILKQVGPVG LYKHFFCDPL CIANIKTIKP HILFYTTESC ILQDFKVAIC
     YQNEYLNSVE KHVWLAIHFF KAFQVSKLNH KNKTLISDFL KDFTQLLADQ NFEIVDPTFT
     IHYYV