ID   UL32_VZVD               Reviewed;         585 AA.
AC   P09282;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Packaging protein UL32;
GN   Name=26;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Plays a role in efficient localization of neo-synthesized
CC       capsids to nuclear replication compartments, thereby controlling
CC       cleavage and packaging of virus genomic DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Note=Mainly
CC       cytoplasmic in transfected cell culture. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL32 protein family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be an envelope glycoprotein.
CC       {ECO:0000305}.
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DR   EMBL; X04370; CAA27908.1; -; Genomic_DNA.
DR   PIR; H27343; WZBE26.
DR   SMR; P09282; -.
DR   PRIDE; P09282; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002597; Herpes_env.
DR   Pfam; PF01673; Herpes_env; 1.
DR   PROSITE; PS51988; HERPESVIRUS_UL32; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Metal-binding; Reference proteome; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..585
FT                   /note="Packaging protein UL32"
FT                   /id="PRO_0000116019"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..193
FT                   /note="Zinc finger 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   REGION          408..491
FT                   /note="Zinc finger 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         107
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         110
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         187
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         193
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         408
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         411
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         484
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
FT   BINDING         491
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01332"
SQ   SEQUENCE   585 AA;  65695 MW;  8C7BB93E2A12FC15 CRC64;
     MDRVESEEPM DGFESPVFSE NTSSNSGWCS DAFSDSYIAY NPALLLKNDL LFSELLFASH
     LINVPRAIEN NVTYEASSAV GVDNEMTSST TEFIEEIGDV LALDRACLVC RTLDLYKRKF
     GLTPEWVADY AMLCMKSLAS PPCAVVTFSA AFEFVYLMDR YYLCRYNVTL VGSFARRTLS
     LLDIQRHFFL HVCFRTDGGL PGIRPPPGKE MANKVRYSNY SFFVQAVVRA ALLSISTSRL
     DETETRKSFY FNQDGLTGGP QPLAAALANW KDCARMVDCS SSEHRTSGMI TCAERALKED
     IEFEDILIDK LKKSSYVEAA WGYADLALLL LSGVATWNVD ERTNCAIETR VGCVKSYWQA
     NRIENSRDVP KQFSKFTSED ACPEVAFGPI LLTTLKNAKC RGRTNTECML CCLLTIGHYW
     IALRQFKRDI LAYSANNTSL FDCIEPVINA WSLDNPIKLK FPFNDEGRFI TIVKAAGSEA
     VYKHLFCDLL CALSELQTNP KILFAHPTTA DKEVLELYKA QLAAQNRFEG RVCAGLWTLA
     YAFKAYQIFP RKPTANAAFI RDGGLMLRRH AISLVSLEHT LSKYV