ID   UL33_HHV6U              Reviewed;         347 AA.
AC   P52380; Q69547;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   23-FEB-2022, entry version 74.
DE   RecName: Full=G-protein coupled receptor homolog U12;
GN   Name=U12; Synonyms=P1RF1;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Probable G-protein coupled receptor.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-30 is the initiator.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X83413; CAA58439.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58440.1; -; Genomic_DNA.
DR   SMR; P52380; -.
DR   PRIDE; P52380; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..347
FT                   /note="G-protein coupled receptor homolog U12"
FT                   /id="PRO_0000070241"
FT   TRANSMEM        36..56
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..124
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   REGION          321..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..338
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        101..176
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   347 AA;  39746 MW;  33DA730AD9059821 CRC64;
     MDTVIELSKL QFKGNASCTS TPTLKTARIM ESAVTGITLT TSIPMIIIVV TTMILYHRVA
     KHNATSFYVI TLFASDFVLM WCVFFMTVNR KQLFSFNRFF CQLVYFIYHA VCSYSISMLA
     IIATIRYKTL HRRKKTESKT SSTGRNIGIL LLASSMCAIP TALFVKTNGM KKTGKCVVYI
     SSKKAYELFL AVKIVFSFIW GVLPTMVFSF FYVIFCKALH DVTEKKYKKT LFFIRILLLS
     FLLIQIPYIA ILICEIAFLY MPQNTCFWLA RVEILQLIIR LMPQVHCFSN PLVYAFTGGE
     LRNRFTACFQ SFFPKTLCST QKRKDSDASE HDQNSKSKAS VEKNQPL