CA162_HUMAN
ID CA162_HUMAN Reviewed; 155 AA.
AC Q8NEQ5; Q5QNZ1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Transmembrane protein C1orf162;
GN Name=C1orf162;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NEQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NEQ5-2; Sequence=VSP_028124;
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DR EMBL; AL390195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017973; AAH17973.1; -; mRNA.
DR EMBL; BG545926; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS72837.1; -. [Q8NEQ5-2]
DR CCDS; CCDS837.1; -. [Q8NEQ5-1]
DR RefSeq; NP_001287763.1; NM_001300834.1. [Q8NEQ5-2]
DR RefSeq; NP_777556.1; NM_174896.3. [Q8NEQ5-1]
DR RefSeq; XP_011539014.1; XM_011540712.2.
DR RefSeq; XP_016855812.1; XM_017000323.1. [Q8NEQ5-2]
DR AlphaFoldDB; Q8NEQ5; -.
DR SMR; Q8NEQ5; -.
DR BioGRID; 126110; 7.
DR IntAct; Q8NEQ5; 3.
DR STRING; 9606.ENSP00000344218; -.
DR iPTMnet; Q8NEQ5; -.
DR PhosphoSitePlus; Q8NEQ5; -.
DR BioMuta; C1orf162; -.
DR DMDM; 74751257; -.
DR EPD; Q8NEQ5; -.
DR MassIVE; Q8NEQ5; -.
DR PaxDb; Q8NEQ5; -.
DR PeptideAtlas; Q8NEQ5; -.
DR PRIDE; Q8NEQ5; -.
DR ProteomicsDB; 73199; -. [Q8NEQ5-1]
DR ProteomicsDB; 73200; -. [Q8NEQ5-2]
DR Antibodypedia; 33811; 45 antibodies from 9 providers.
DR DNASU; 128346; -.
DR Ensembl; ENST00000343534.9; ENSP00000344218.5; ENSG00000143110.12. [Q8NEQ5-1]
DR Ensembl; ENST00000369718.4; ENSP00000358732.3; ENSG00000143110.12. [Q8NEQ5-2]
DR GeneID; 128346; -.
DR KEGG; hsa:128346; -.
DR MANE-Select; ENST00000369718.4; ENSP00000358732.3; NM_001300834.2; NP_001287763.1. [Q8NEQ5-2]
DR UCSC; uc001ebe.4; human. [Q8NEQ5-1]
DR CTD; 128346; -.
DR GeneCards; C1orf162; -.
DR HGNC; HGNC:28344; C1orf162.
DR HPA; ENSG00000143110; Tissue enhanced (bone marrow, lymphoid tissue).
DR neXtProt; NX_Q8NEQ5; -.
DR OpenTargets; ENSG00000143110; -.
DR PharmGKB; PA142672413; -.
DR VEuPathDB; HostDB:ENSG00000143110; -.
DR eggNOG; ENOG502TE6S; Eukaryota.
DR GeneTree; ENSGT00390000015005; -.
DR HOGENOM; CLU_136856_0_0_1; -.
DR InParanoid; Q8NEQ5; -.
DR OMA; PYTEKQG; -.
DR OrthoDB; 1580985at2759; -.
DR PhylomeDB; Q8NEQ5; -.
DR TreeFam; TF338377; -.
DR PathwayCommons; Q8NEQ5; -.
DR SignaLink; Q8NEQ5; -.
DR BioGRID-ORCS; 128346; 9 hits in 1070 CRISPR screens.
DR ChiTaRS; C1orf162; human.
DR GenomeRNAi; 128346; -.
DR Pharos; Q8NEQ5; Tdark.
DR PRO; PR:Q8NEQ5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NEQ5; protein.
DR Bgee; ENSG00000143110; Expressed in granulocyte and 150 other tissues.
DR Genevisible; Q8NEQ5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037763; C1orf162.
DR PANTHER; PTHR37997; PTHR37997; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..155
FT /note="Transmembrane protein C1orf162"
FT /id="PRO_0000304787"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 140
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3U7U4"
FT VAR_SEQ 69..93
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028124"
FT VARIANT 3
FT /note="G -> S (in dbSNP:rs6703267)"
FT /id="VAR_035106"
SQ SEQUENCE 155 AA; 16886 MW; C977B5FE7366D888 CRC64;
MGGNGSTCKP DTERQGTLST AAPTTSPAPC LSNHHNKKHL ILAFCAGVLL TLLLIAFIFL
IIKSYRKYRR ERLPISPGPL LRWVPLLSGT MADHSKPQAP DPHSDPPAKL SSIPGESLTY
ASTTFKLSEE KSNHLAENHS ADFDPIVYAQ IKVTN
