ID   UL33_RCMVM              Reviewed;         387 AA.
AC   O12000;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   02-JUN-2021, entry version 90.
DE   RecName: Full=G-protein coupled receptor homolog R33;
OS   Rat cytomegalovirus (strain Maastricht).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Muromegalovirus.
OX   NCBI_TaxID=79700;
OH   NCBI_TaxID=10114; Rattus.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9499096; DOI=10.1128/jvi.72.3.2352-2363.1998;
RA   Beisser P.S., Vink C., Van Dam J.G., Grauls G., Vanherle S.J.,
RA   Bruggeman C.A.;
RT   "The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an
RT   essential role in the pathogenesis of viral infection.";
RL   J. Virol. 72:2352-2363(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10906222; DOI=10.1128/jvi.74.16.7656-7665.2000;
RA   Vink C., Beuken E., Bruggeman C.A.;
RT   "Complete DNA sequence of the rat cytomegalovirus genome.";
RL   J. Virol. 74:7656-7665(2000).
CC   -!- FUNCTION: Plays an important role in vivo, in particular in the
CC       dissemination to or replication in the salivary gland.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF232689; AAC58815.1; -; Genomic_DNA.
DR   RefSeq; NP_064138.1; NC_002512.2.
DR   SMR; O12000; -.
DR   GeneID; 940282; -.
DR   KEGG; vg:940282; -.
DR   Proteomes; UP000008288; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Host cell membrane;
KW   Host membrane; Membrane; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..387
FT                   /note="G-protein coupled receptor homolog R33"
FT                   /id="PRO_0000070244"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..61
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        62..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..94
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..129
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        130..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..169
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..268
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..285
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..309
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..387
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          368..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..387
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        20
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   387 AA;  43160 MW;  EF80D3F10344D6AE CRC64;
     MDVLLGTEEL EDELHQLHFN YTCVPSLGLS VARDAETAVN FLIVLVGGPM NFLVLATQML
     SNRSYSVSTP TLYMTNLYLA NLLTVATLPF LMLSNRGLVG SSPEGCKIAA LAYYATCTAG
     FATLMLIAIN RYRVIHQRTR SGAGSKRQTY AVLAVTWLAS LMCASPAPLY ATVMAHDSAD
     ALAFETCIIY FSYDQVKTVL ATFKILITMI WGITPVVMMS WFYVFFYRRL KLTSYRRRSQ
     TLTFVTTLML SFLVVQTPFV AIMSYDSYGV LNWPINCDTI NKRDAVSMLA RVVPNFHCLL
     NPVLYAFLGR DFNKRFILCI SGKLFSRRRA LRERAGLGAQ IVGPVCALPS KTVTLSEETR
     DLSQEIRRLR ALGRPPPPPP PPPPPNC