ID   UL34_HCMVA              Reviewed;         407 AA.
AC   P16812; Q7M6P9;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   02-JUN-2021, entry version 49.
DE   RecName: Full=Transcriptional regulator UL34;
GN   Name=UL34;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- FUNCTION: Acts as a transcriptional repressor of the US3 gene
CC       expression through a specific DNA sequence named the transcriptional
CC       repressive element (tre). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL34 protein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA35393.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X17403; CAA35393.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BK000394; DAA00139.1; -; Genomic_DNA.
DR   PIR; S09797; S09797.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..407
FT                   /note="Transcriptional regulator UL34"
FT                   /id="PRO_0000115317"
FT   REGION          267..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  45381 MW;  CB66A191F3D0B70A CRC64;
     MNFIITTRDF SNDDSVLRAA EMRDNVAGSI SKAYKGTVRA EGKKKLLLKH LPVPPGGCSR
     RNSNLFVFCT ERDYRKFHQG IAQLKRAPAE LDPHEIQQVT ASIRCRLQPS LREPPTPADE
     LQTAVSRVCA LFNQLVFTAQ LRHYCEHQDK VVSYARDELT KRCGEKSALG VEVHQLVALL
     PHERHRELCH VLIGLLHQTP HMWARSIRLI GHLRHYLQNS FLHLLMNSGL DIAQVFDGCY
     HSEAYRMLFQ IGHTDSVSAA LELSHGAAAG PPEADENNDE GEEDDDELRH SDPAPLHESK
     KPRNARRPRT RVPPHEQKPE ENEEEEEELF PSCKATAAFL RAEPSVSNDD GNGGERCDTL
     ATALRHRADE EDGPLASQTA VRVAATPSPS VTPALTPVTS PITPLCI