ID   UL34_HCMVM              Reviewed;         407 AA.
AC   F5HC16;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 22.
DE   RecName: Full=Transcriptional regulator UL34;
GN   Name=UL34;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Acts as a transcriptional repressor of the US3 gene
CC       expression through a specific DNA sequence named the transcriptional
CC       repressive element (tre). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL34 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31599.1; -; Genomic_DNA.
DR   RefSeq; YP_081493.1; NC_006273.2.
DR   PRIDE; F5HC16; -.
DR   DNASU; 3077500; -.
DR   GeneID; 3077500; -.
DR   KEGG; vg:3077500; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..407
FT                   /note="Transcriptional regulator UL34"
FT                   /id="PRO_0000416717"
FT   REGION          268..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  45403 MW;  D77DCC2F14587A00 CRC64;
     MNFIITTRDF SNDDSVLRAA EMRDNVAGSI SKAYKGTVRA EGKKKLLLKH LPVPPGGCSR
     RNSNLFVFCT ERDYRKFHQG IAQLKRAPAE LDPHEIQQVT ASIRCRLQPS LREPPTPADE
     LQTAVSRVCA LFNQLVFTAQ LRHYCEHQDK VVSYARDELT KRCGEKSALG VEVHQLVALL
     PHERHRELCH VLIGLLHQTP HMWARSIRLI GHLRHYLQNS FLHLLMNSGL DIAQVFDGCY
     HSEAYRMLFQ IGHTDSVSAA LELSHSAAAG PPEADENNDE GEEDDDELRH SDPAPLHDSK
     KPRNARRPRT RVPPHEQKPE ENEEEEEELF PSCKATAAFL RAEPSVSNDD GNGGERCDTL
     ATALRHRADE EDGPLASQTS VRVAATPSPS VTSALTPVTS PITPLCI