ID   UL34_HCMVT              Reviewed;         407 AA.
AC   B9VXK4;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   02-JUN-2021, entry version 26.
DE   RecName: Full=Transcriptional regulator UL34;
GN   Name=UL34;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19553388; DOI=10.1099/vir.0.013250-0;
RA   Bradley A.J., Lurain N.S., Ghazal P., Trivedi U., Cunningham C.,
RA   Baluchova K., Gatherer D., Wilkinson G.W., Dargan D.J., Davison A.J.;
RT   "High-throughput sequence analysis of variants of human cytomegalovirus
RT   strains Towne and AD169.";
RL   J. Gen. Virol. 90:2375-2380(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11390608; DOI=10.1128/jvi.75.13.6062-6069.2001;
RA   LaPierre L.A., Biegalke B.J.;
RT   "Identification of a novel transcriptional repressor encoded by human
RT   cytomegalovirus.";
RL   J. Virol. 75:6062-6069(2001).
CC   -!- FUNCTION: Acts as a transcriptional repressor of the US3 gene
CC       expression through a specific DNA sequence named the transcriptional
CC       repressive element (tre). {ECO:0000269|PubMed:11390608}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:11390608}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL34 protein family. {ECO:0000305}.
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DR   EMBL; FJ616285; ACM48024.1; -; Genomic_DNA.
DR   Proteomes; UP000006907; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..407
FT                   /note="Transcriptional regulator UL34"
FT                   /id="PRO_0000416716"
FT   REGION          268..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   407 AA;  45358 MW;  B5E3B5CE291B29DB CRC64;
     MNFIITTRDF SNDDSVLRAA EMRDNVAGSI SKAYKGTVRA EGKKKLLLKH LPVPPGGCSR
     RNSNLFVFCT ERDYRKFHQG IAQLKRAPAE LDPHEIQQVT ASIRCRLQPS LREPPTPADE
     LQTAVSRVCA LFNQLVFTAQ LRHYCEHQDK VVSYARDELT KRCGEKSALG VEVHQLVALL
     PHERHRELCH VLIGLLHQTP HMWARSIRLI GHLRHYLQNS FLHLLMNSGL DIAQVFDGCY
     HSEAYRMLFQ IGHTDSVSAA LELSHSAAAG PPEADENNDE GEEDDDELRH SDPAPLHESK
     KPRNARRPRT RVPPHEQKPE ENEEEEEELF PSCKATAAFL RAEPSVSNDD GNGGERCDTL
     ATALRHCADE EDGPLASQTA VRVAATPSPS VTPALTPVTS PITPLCI