ID   UL38_HHV6U              Reviewed;         389 AA.
AC   Q69554; Q69043;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=Apoptosis inhibitor U19;
GN   Name=U19; Synonyms=EJLF4;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis to
CC       facilitate efficient viral replication. Promotes stabilization and
CC       inactivation of host TP53 through interaction with host MDM2.
CC       {ECO:0000250|UniProtKB:Q9WT45}.
CC   -!- SUBUNIT: Interacts with host MDM2; this interaction leads to the
CC       stabilization of host TP53. {ECO:0000250|UniProtKB:Q9WT45}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:F5HG98}.
CC       Host nucleus {ECO:0000250|UniProtKB:F5HG98}. Note=localized in the host
CC       nucleus at early times postinfection and then increases in both nuclear
CC       and cytoplasmic compartments during the course of infection.
CC       {ECO:0000250|UniProtKB:F5HG98}.
CC   -!- SIMILARITY: Belongs to the beta-herpesvirinae UL38 protein family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16726.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L25528; AAA16726.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58399.1; -; Genomic_DNA.
DR   PIR; T09313; T09313.
DR   RefSeq; NP_042912.1; NC_001664.2.
DR   PRIDE; Q69554; -.
DR   DNASU; 1487945; -.
DR   GeneID; 1487945; -.
DR   KEGG; vg:1487945; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Apoptosis inhibitor U19"
FT                   /id="PRO_0000342574"
SQ   SEQUENCE   389 AA;  43316 MW;  A2151E588BECC0BE CRC64;
     MAFTGDELAR MLQFKDKMIS SAGLALKFEK VVQEAMASGI VLQHITCIKV RICDNSDILS
     DRQLRSLLIN GLYPFEGRMS MFGVTEEWEG ASAAPERQVV FLLSSTGQVL GYEDGVVFYL
     SPTFSDFWTT AMEFSCQNAI LSNFIAQKSR DEYIDQFQKY FTRMRHTPIF LTGVLPRRFQ
     KVESSACVEE DARASMRPIQ CDSFGVKDTF CRPTEELLQP SANKDVGGKV CMSLSCREDN
     SARHCTIYGL TETRGIKIMF SRHTQTDRSE VMCNAATQTG DVVDNSSETL FLGKNLVHQS
     ILETEVKTTA KNTFDVSNPR IDSVYDTTVF GAMATDDVGC ENVQGGASLA QEKPLKGYCI
     TATPSECKPN IHWLKSPEKT VQESAAVLR