ID   UL38_HHV6Z              Reviewed;         389 AA.
AC   Q9WT45; Q77PV3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   29-SEP-2021, entry version 49.
DE   RecName: Full=Apoptosis inhibitor U19;
GN   Name=U19;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HST;
RX   PubMed=10482554; DOI=10.1128/jvi.73.10.8053-8063.1999;
RA   Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T.,
RA   Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of human herpesvirus 6 variants A
RT   and B.";
RL   J. Virol. 73:8053-8063(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
RN   [3]
RP   FUNCTION.
RX   PubMed=23555634; DOI=10.1371/journal.pone.0059223;
RA   Kofod-Olsen E., Moller J.M., Schleimann M.H., Bundgaard B., Bak R.O.,
RA   Oster B., Mikkelsen J.G., Hupp T., Hollsberg P.;
RT   "Inhibition of p53-dependent, but not p53-independent, cell death by U19
RT   protein from human herpesvirus 6B.";
RL   PLoS ONE 8:E59223-E59223(2013).
RN   [4]
RP   FUNCTION, INTERACTION WITH HOST MDM2, AND SUBCELLULAR LOCATION.
RX   PubMed=24314634; DOI=10.1016/j.virol.2013.10.002;
RA   Kofod-Olsen E., Pettersson S., Wallace M., Abduljabar A.B., Oster B.,
RA   Hupp T., Hollsberg P.;
RT   "Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for
RT   HDM2 binding and p53 stabilization.";
RL   Virology 448:33-42(2014).
CC   -!- FUNCTION: Plays a role in the inhibition of host apoptosis to
CC       facilitate efficient viral replication. Promotes stabilization and
CC       inactivation of host TP53 through interaction with host MDM2.
CC       {ECO:0000269|PubMed:23555634, ECO:0000269|PubMed:24314634}.
CC   -!- SUBUNIT: Interacts with host MDM2; this interaction leads to the
CC       stabilization of host TP53. {ECO:0000269|PubMed:24314634}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:F5HG98}.
CC       Host nucleus {ECO:0000269|PubMed:24314634}. Note=localized in the host
CC       nucleus at early times postinfection and then increases in both nuclear
CC       and cytoplasmic compartments during the course of infection.
CC       {ECO:0000250|UniProtKB:F5HG98}.
CC   -!- SIMILARITY: Belongs to the beta-herpesvirinae UL38 protein family.
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DR   EMBL; AF157706; AAD49631.1; -; Genomic_DNA.
DR   EMBL; AB021506; BAA78240.1; -; Genomic_DNA.
DR   PIR; T43979; T43979.
DR   RefSeq; NP_050199.1; NC_000898.1.
DR   PRIDE; Q9WT45; -.
DR   DNASU; 1497015; -.
DR   GeneID; 1497015; -.
DR   KEGG; vg:1497015; -.
DR   Proteomes; UP000006930; Genome.
DR   Proteomes; UP000142685; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Apoptosis inhibitor U19"
FT                   /id="PRO_0000408422"
SQ   SEQUENCE   389 AA;  42901 MW;  EF3A9CF4DD5CB09E CRC64;
     MAFTGDELAR MLQFKDKMIS SAGSALRFEK VVQEAMASGI VLQHITCIKV RICDNSDILS
     DRQLRCLLIN GLYPFEGRMS MFGVTEEWEG ASAAPERQVV FLLSSTGQVL GYEDGVIFYL
     SPTFSDFWTT AMEFSCQNAI LSNFIAQKSR DEYSDQFQKY FTRMRHTPIS LTGVLPRRFQ
     KVESGACVEE DARASMRPIQ SDSFGAKGPF CWPTEELLQP SAKKDVGGTV CMALSCQEDN
     SARHCTIYGL TKTPGIKIML SRHTQTDRSE AMCDAATQTE DVVDNSSETL FLGGNLVHQS
     ILETEVQATA KNTFDVSDPR IDSVYDTTVV GAMATDDVGC KHVQGGASLA QEKPLKGYCI
     IATPSECKPN IHWLKSPENA VHESAAVLR