ID   UL40_HCMVM              Reviewed;         221 AA.
AC   Q6SW92; D2K3K7;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 47.
DE   RecName: Full=Protein UL40;
DE   Flags: Precursor;
GN   Name=UL40;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the protection against host NK cell
CC       cytotoxicity by up-regulating the cell surface expression of HLA-E
CC       independent of TAP (HLA-E has an inhibitory effect on the cytotoxic
CC       activity of the NK cell). Promotes also cell surface expression of
CC       UL18, another viral protein involved in NK cell evasion (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL40 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31604.1; -; Genomic_DNA.
DR   RefSeq; YP_081498.1; NC_006273.2.
DR   PRIDE; Q6SW92; -.
DR   DNASU; 3077540; -.
DR   GeneID; 3077540; -.
DR   KEGG; vg:3077540; -.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0039671; P:evasion by virus of host natural killer cell activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019624; Herpes_UL40.
DR   Pfam; PF10682; UL40; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Modulation of host NK-cell activity by virus;
KW   Reference proteome; Signal; Viral immunoevasion.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..221
FT                   /note="Protein UL40"
FT                   /id="PRO_0000418285"
FT   REGION          15..23
FT                   /note="HLA-E-binding epitope"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  24366 MW;  3112380E3B1E2692 CRC64;
     MNKFSNTRIG FTCAVMAPRT LILTVGLLCM RIRSLLSSPV ETTVTTAGVT SAHGPLCPLV
     FQGWAYAVYH QGDMVLMTLD VYCCRQTSSN TVVAFSHHPA DNTLLIEVGN NTRRHVDGIS
     CQDHFRAQHQ DCPAQTVHVR GVNESAFGLT HLQSCCLNEH SQLSERVAYH LKLRPATFGL
     ETWAMYTVGI LALGSFSSFY SQIARSLGVL PNDHHYALKK A