CA167_HUMAN
ID CA167_HUMAN Reviewed; 1468 AA.
AC Q5SNV9; Q8NDA9; Q8NDF3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized protein C1orf167;
GN Name=C1orf167;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 642-1468 (ISOFORM 1), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 859-1468 (ISOFORM 2), AND VARIANTS ARG-782;
RP CYS-800; ILE-848; HIS-944; ARG-955 AND GLY-1451.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SNV9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SNV9-2; Sequence=VSP_028420;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL953897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL833926; CAD38782.1; -; mRNA.
DR EMBL; AL834308; CAD38978.2; -; mRNA.
DR RefSeq; NP_001010881.1; NM_001010881.1.
DR AlphaFoldDB; Q5SNV9; -.
DR BioGRID; 129889; 3.
DR IntAct; Q5SNV9; 1.
DR STRING; 9606.ENSP00000414909; -.
DR iPTMnet; Q5SNV9; -.
DR PhosphoSitePlus; Q5SNV9; -.
DR BioMuta; C1orf167; -.
DR DMDM; 158706475; -.
DR MassIVE; Q5SNV9; -.
DR MaxQB; Q5SNV9; -.
DR PaxDb; Q5SNV9; -.
DR PeptideAtlas; Q5SNV9; -.
DR PRIDE; Q5SNV9; -.
DR ProteomicsDB; 63764; -. [Q5SNV9-1]
DR ProteomicsDB; 63765; -. [Q5SNV9-2]
DR Antibodypedia; 51586; 26 antibodies from 7 providers.
DR DNASU; 284498; -.
DR Ensembl; ENST00000433342.6; ENSP00000414909.3; ENSG00000215910.8.
DR GeneID; 284498; -.
DR KEGG; hsa:284498; -.
DR UCSC; uc057chg.1; human. [Q5SNV9-1]
DR CTD; 284498; -.
DR DisGeNET; 284498; -.
DR GeneCards; C1orf167; -.
DR HGNC; HGNC:25262; C1orf167.
DR HPA; ENSG00000215910; Tissue enriched (testis).
DR neXtProt; NX_Q5SNV9; -.
DR VEuPathDB; HostDB:ENSG00000215910; -.
DR eggNOG; ENOG502S8BN; Eukaryota.
DR HOGENOM; CLU_266541_0_0_1; -.
DR InParanoid; Q5SNV9; -.
DR OMA; FRPTEAF; -.
DR OrthoDB; 759766at2759; -.
DR PhylomeDB; Q5SNV9; -.
DR TreeFam; TF340835; -.
DR PathwayCommons; Q5SNV9; -.
DR SignaLink; Q5SNV9; -.
DR BioGRID-ORCS; 284498; 1 hit in 165 CRISPR screens.
DR ChiTaRS; C1orf167; human.
DR GenomeRNAi; 284498; -.
DR Pharos; Q5SNV9; Tdark.
DR PRO; PR:Q5SNV9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5SNV9; protein.
DR Bgee; ENSG00000215910; Expressed in left testis and 94 other tissues.
DR ExpressionAtlas; Q5SNV9; baseline and differential.
DR InterPro; IPR031473; DUF4684.
DR PANTHER; PTHR38493; PTHR38493; 1.
DR Pfam; PF15736; DUF4684; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1468
FT /note="Uncharacterized protein C1orf167"
FT /id="PRO_0000306118"
FT REGION 119..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1418..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..482
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1306
FT /note="L -> LRARSC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_028420"
FT VARIANT 453
FT /note="P -> S (in dbSNP:rs6668699)"
FT /id="VAR_035266"
FT VARIANT 544
FT /note="R -> Q (in dbSNP:rs4845880)"
FT /id="VAR_035267"
FT VARIANT 602
FT /note="R -> W (in dbSNP:rs6667720)"
FT /id="VAR_035268"
FT VARIANT 782
FT /note="W -> R (in dbSNP:rs6699881)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035269"
FT VARIANT 800
FT /note="R -> C (in dbSNP:rs7538516)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035270"
FT VARIANT 848
FT /note="S -> I (in dbSNP:rs6697244)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035271"
FT VARIANT 944
FT /note="R -> H (in dbSNP:rs4846043)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035272"
FT VARIANT 955
FT /note="W -> R (in dbSNP:rs4846044)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035273"
FT VARIANT 1215
FT /note="R -> H (in dbSNP:rs3737967)"
FT /id="VAR_035274"
FT VARIANT 1295
FT /note="C -> S (in dbSNP:rs1537514)"
FT /id="VAR_035275"
FT VARIANT 1451
FT /note="R -> G (in dbSNP:rs868014)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_035276"
SQ SEQUENCE 1468 AA; 162423 MW; 19B2A63B0053550D CRC64;
MTRMSCPWGS YQWEPGACPA APRGIGGGDM AGGIPDVRGL QEAALGAGRS QEEARLVEEA
QTPVMLPQDS GQRVEEVPGD LMAKRMSLIL HVQKLPWDHV PCLRRTRQNL YQDVGGHAHG
SGLGGAKRGA ARSALRRPLP PATCRPAGIV SGPSPRLDSN PTGAHLIKQT RPLTVEWTKD
TPVPEPMELR SDASHKENVS PKPAALPKPG KRLKQRRFRR SLGIGLSGRH DQWVPGCQVE
RGGPAATPSP GAVLDQEPCR VQTNLASPGP RLGLALKDTT GQLVNSSFWQ QSNLQSLARR
RQGKAREFAI QQSNLSINET SSPHLCPEPG GSSGPHKLPW GPLLSQEPLA RPSSCLRQSG
LPAPGTPSGD FRPTEAFAPL DGHTQPGLRS WGGLGSWRSR LVGEPLTLED LAVPSQNQTQ
APSRAAVHQL LASVHCLAQE AARLRCQAPQ EPPAWGVSPK QKGEEGAPRE RVHREEERTA
FHLSDTVPAS SASKNKAQNI TAPESEAICW QLLSRCFRSW RHLVKRQREP AAAAVALGRW
QLLRKCLQAL WLREAQLEAA WGQYTKVLLV RSFREVSGLQ VGPGGRVKQC PGSLREEEIA
QRLLSHPRQR TDSRHERVQI LQALQLAVFF LWCQQKKRAR QERETLRKAT RATQRTGSFP
QAWHSTAAGV AWVAPLSPQH QRAWLCRCFG AWQQFVQRGS RYRDHLADRR TGTLRKCLEQ
WVRMKQLRES DGAKVTQLSL CRQKAGREAV YTAGPGACGL GAVGQAQGQQ EQGRGSLQDA
CWTLALCWAL LLWKMRLFQR QWANSFFQGL QQRMLQRSLR WWHLRALGPD ATSSCTKTPS
ALEPLSSSTL QDSLEKVPRA PTLPDTLQGS LLWAAGQRQQ GQCLLLWQAR AQQFQGTARW
YQHTRQRRIF LSWSRWATAQ WAWRELASHR AWDRTCRAVL GLWRQRLLQS RLVEWWAQER
GWRLARDALC HWHSCWQGQQ FLHEKCQTWV QVHLQGLQKV VFRSWQQAAA HQRCTVTRPE
QLLLQSYFQA WCEVVRDTGV LRAQHQAFQD GLRRRALGAV FATWREAQEV AAGAQEQRVA
QASLARWRSC GQQGQEDGQQ KKARAPQAFP AWPVAPGMHH EAQQQAGESA GAQAAQCWTW
CWALWVHESC RGQVSRAHAS WKPRAWVLEA SVQSAVRGGV QRAILTQLRP AELRRFLRTV
QLRVRLGLPG AGKTRSCWTQ ATELVPPAPS LQCSLGGRRK PRGTAWAQRC REHSLCPAFQ
LWPQWPGQSS WVPGLPLWTR DQGPRAHSSP EPRACKAQSK AHKRRLRILE KQAQAHGSAL
LLALKGHDAL GHQEEVPAAP VPRGTASRAA GFPAGQVPGS GMAALGGCPR GRAAGADPAQ
GVAPEMGLAD VVAADPATAS GSAVTAAGRW AFKKWHQRLA ARSPRRGAAS SPRPWSKPGP
KGPESGQEAA RAPRGWGLGA EHGAQLQL
