ID   UL43_HCMVA              Reviewed;         423 AA.
AC   P16781; O39921; Q7M6F7;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   02-JUN-2021, entry version 65.
DE   RecName: Full=Tegument protein UL43;
GN   Name=UL43;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RX   PubMed=9371656; DOI=10.1128/jvi.71.12.9833-9836.1997;
RA   Dargan D.J., Jamieson F.E., Maclean J., Dolan A., Addison C., McGeoch D.J.;
RT   "The published DNA sequence of human cytomegalovirus strain AD169 lacks 929
RT   base pairs of DNA affecting genes UL42 and UL43.";
RL   J. Virol. 71:9833-9836(1997).
RN   [3]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [6]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
RN   [7]
RP   SUBCELLULAR LOCATION.
RX   PubMed=12029146; DOI=10.1099/0022-1317-83-6-1315;
RA   Adair R., Douglas E.R., Maclean J.B., Graham S.Y., Aitken J.D.,
RA   Jamieson F.E., Dargan D.J.;
RT   "The products of human cytomegalovirus genes UL23, UL24, UL43 and US22 are
RT   tegument components.";
RL   J. Gen. Virol. 83:1315-1324(2002).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000269|PubMed:12029146}.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- CAUTION: PubMed:2161319 sequence lacks the c-terminus due to an
CC       internal deletion. {ECO:0000305}.
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DR   EMBL; X17403; CAA35402.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Y13735; CAA74075.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00235.1; -; Genomic_DNA.
DR   PIR; S09806; S09806.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..423
FT                   /note="Tegument protein UL43"
FT                   /id="PRO_0000116323"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  47704 MW;  317E9B25ABD49256 CRC64;
     MEKTPAETTA VSAGNVPRDS IPCITNVSAD TRGRTRPSRP ATVPQRRPAR IGHFRRRSAS
     LSFLDWPDGS VTEGVRTTSA SVAASAARFD EIRRRRQSIN DEMKERTLED ALAVELVNET
     FRCSVTSDAR KDLQKLVRRV SGTVLRLSWP NGWFFTYCDL LRVGYFGHLN IKGLEKTFLC
     CDKFLLPVGT VSRCEAIGRP PLPVLIGEGG RVYVYSPVVE SLYLVSRSGF RGFVQEGLRN
     YAPLREELGY VRFETGGDVG REFMLARDLL ALWRLCMKRE GSIFSWRDGN EALTTVVLNG
     SQTYEDPAHG NWLKETCSLN VLQVFVVRAV PVESQQRLDI SILVNESGAV FGVHPETRQA
     HFLARGLLGF FRVGFLRFCN NYCFARDCFT HPESVAPAYR ATGCPRELFC RRLRKKKGLF
     ARR