CA168_CONPO
ID CA168_CONPO Reviewed; 62 AA.
AC D9IWN7;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 23-FEB-2022, entry version 28.
DE RecName: Full=Conotoxin Pl168 {ECO:0000303|PubMed:32443665};
DE AltName: Full=Alpha-conotoxin Vt1.24 {ECO:0000312|EMBL:ADJ67510.1};
DE Flags: Precursor;
OS Conus planorbis (Planorbis cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX NCBI_TaxID=97183;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sun T., Liu Z., Dai Q.;
RT "A new alpha-conotoxin Vt1.24 precursor.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-62, PROTEIN SEQUENCE OF 41-62,
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom, and Venom duct;
RX PubMed=26506909; DOI=10.1002/pmic.201500220;
RA Jin A.H., Vetter I., Himaya S.W., Alewood P.F., Lewis R.J., Dutertre S.;
RT "Transcriptome and proteome of Conus planorbis identify the nicotinic
RT receptors as primary target for the defensive venom.";
RL Proteomics 15:4030-4040(2015).
RN [3]
RP FUNCTION, SYNTHESIS OF 41-62, AND STRUCTURE BY NMR OF 41-62.
RX PubMed=32443665; DOI=10.3390/biomedicines8050128;
RA Wilson D.T., Bansal P.S., Carter D.A., Vetter I., Nicke A., Dutertre S.,
RA Daly N.L.;
RT "Characterisation of a novel A-superfamily conotoxin.";
RL Biomedicines 8:0-0(2020).
CC -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC channels. {ECO:0000305|PubMed:32443665}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26506909}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:26506909}.
CC -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/8 pattern.
CC {ECO:0000305}.
CC -!- PTM: Both Pro-53 and Pro-62 are not in cis/trans isomerization.
CC {ECO:0000305|PubMed:32443665}.
CC -!- MISCELLANEOUS: Does not show activity on a range of nAChRs (alpha-3-
CC beta-2/CHRNA3-CHRNB2, alpha-4-beta-2/CHRNA4-CHRNB2, and alpha-
CC 7/CHRNA7), calcium and sodium channels. {ECO:0000305|PubMed:32443665}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
CC -!- CAUTION: Shows a different disulfide-stabilized fold, despite
CC containing the conserved cysteine framework and disulfide connectivity
CC of classical alpha-conotoxins. {ECO:0000305|PubMed:32443665}.
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DR EMBL; HM211181; ADJ67510.1; -; mRNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..40
FT /evidence="ECO:0000305|PubMed:32443665"
FT /id="PRO_0000453213"
FT PEPTIDE 41..62
FT /note="Conotoxin Pl168"
FT /evidence="ECO:0000269|PubMed:26506909"
FT /id="PRO_5003125753"
FT DISULFID 46..52
FT /evidence="ECO:0000305|PubMed:32443665"
FT DISULFID 47..61
FT /evidence="ECO:0000305|PubMed:32443665"
SQ SEQUENCE 62 AA; 6829 MW; 5F7F8A8A843028FA CRC64;
MGMRMMFTVF LLVVLATTVV SFTLDRASDG ANAAADLVAR GIRGNCCMFH TCPIDYSRFY
CP
