ID   CA16A_CONLE             Reviewed;          61 AA.
AC   P0CAQ6; A1X8B7; A6M937; A6M939;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Alpha-conotoxin-like Lp1.6a {ECO:0000303|PubMed:17400270};
DE   Flags: Precursor;
OS   Conus leopardus (Leopard cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX   NCBI_TaxID=101306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND AMIDATION AT CYS-60.
RX   PubMed=17400270; DOI=10.1016/j.toxicon.2007.02.011;
RA   Yuan D.-D., Han Y.-H., Wang C.-G., Chi C.-W.;
RT   "From the identification of gene organization of alpha conotoxins to the
RT   cloning of novel toxins.";
RL   Toxicon 49:1135-1149(2007).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:17400270}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:17400270}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/6 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD48796.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; DQ311057; ABD33849.1; -; Genomic_DNA.
DR   EMBL; DQ359145; ABD48796.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P0CAQ6; -.
DR   ConoServer; 547; Lp1.6a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Amidation; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
KW   Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..44
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000370652"
FT   PEPTIDE         45..60
FT                   /note="Alpha-conotoxin-like Lp1.6a"
FT                   /evidence="ECO:0000305|PubMed:17400270"
FT                   /id="PRO_0000376850"
FT   MOD_RES         45
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250|UniProtKB:D4HRK4"
FT   MOD_RES         60
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000305|PubMed:17400270"
FT   DISULFID        47..53
FT                   /evidence="ECO:0000250|UniProtKB:K8DWB5"
FT   DISULFID        48..60
FT                   /evidence="ECO:0000250|UniProtKB:K8DWB5"
SQ   SEQUENCE   61 AA;  6739 MW;  F6265D8D68E7722A CRC64;
     MGMRMMFIIF LFVVLATTVV SFTSGRASDG RNAPANNKVS DLIRQFCCGH YDCDFIPNVC
     G