UL56_HHV2H
ID UL56_HHV2H Reviewed; 235 AA.
AC P28282;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 02-JUN-2021, entry version 66.
DE RecName: Full=Protein UL56;
GN Name=UL56;
OS Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10315;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT "Comparative sequence analysis of the long repeat regions and adjoining
RT parts of the long unique regions in the genomes of herpes simplex viruses
RT types 1 and 2.";
RL J. Gen. Virol. 72:3057-3075(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT "The genome sequence of herpes simplex virus type 2.";
RL J. Virol. 72:2010-2021(1998).
RN [3]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH UL11.
RX PubMed=16604447; DOI=10.1007/s11262-005-6871-7;
RA Koshizuka T., Kawaguchi Y., Goshima F., Mori I., Nishiyama Y.;
RT "Association of two membrane proteins encoded by herpes simplex virus type
RT 2, UL11 and UL56.";
RL Virus Genes 32:153-163(2006).
RN [4]
RP FUNCTION, AND INTERACTION WITH HOST NEDD4.
RX PubMed=18353951; DOI=10.1128/jvi.02515-07;
RA Ushijima Y., Koshizuka T., Goshima F., Kimura H., Nishiyama Y.;
RT "Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4
RT and increases its ubiquitination.";
RL J. Virol. 82:5220-5233(2008).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=19835589; DOI=10.1186/1743-422x-6-168;
RA Ushijima Y., Goshima F., Kimura H., Nishiyama Y.;
RT "Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin
RT ligase Nedd4 and has a role in transport and/or release of virions.";
RL Virol. J. 6:168-168(2009).
RN [6]
RP FUNCTION, AND INTERACTION WITH HOST ITCH.
RX PubMed=20682038; DOI=10.1186/1743-422x-7-179;
RA Ushijima Y., Luo C., Kamakura M., Goshima F., Kimura H., Nishiyama Y.;
RT "Herpes simplex virus UL56 interacts with and regulates the Nedd4-family
RT ubiquitin ligase Itch.";
RL Virol. J. 7:179-179(2010).
CC -!- FUNCTION: Plays a role in the transport and release of virions form the
CC host cytoplasm to the extracellular space. Relocalizes host NEDD4, a
CC cytosolic E3 ligase, to cytoplasmic vesicles.
CC {ECO:0000269|PubMed:18353951, ECO:0000269|PubMed:19835589,
CC ECO:0000269|PubMed:20682038}.
CC -!- SUBUNIT: Interacts with host ITCH; this interaction induces
CC ubiquitination and degradation of ITCH (PubMed:20682038). Interacts
CC with host NEDD4; this interaction increases NEDD4 ubiquitination
CC (PubMed:18353951). Interacts with UL11 (PubMed:16604447).
CC {ECO:0000269|PubMed:16604447, ECO:0000269|PubMed:18353951,
CC ECO:0000269|PubMed:20682038}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane
CC {ECO:0000269|PubMed:16604447}; Single-pass membrane protein
CC {ECO:0000255}. Host cytoplasm {ECO:0000269|PubMed:19835589,
CC ECO:0000269|PubMed:20682038}. Note=If expressed alone, is predominantly
CC present in host trans-Golgi network (TGN) and partially in Golgi
CC complex and early endosomes. {ECO:0000269|PubMed:19835589}.
CC -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC essential for viral particle budding. They recruit proteins of the host
CC ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC ESCRT-associated proteins. UL56 contains three L domains: the PPXY
CC motifs which are involved in the interaction with ITCH, a member of the
CC NEDD4 family. {ECO:0000250|UniProtKB:P10240}.
CC -!- SIMILARITY: Belongs to the herpesviridae UL56 family. {ECO:0000305}.
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DR EMBL; D10471; BAA01271.1; -; Genomic_DNA.
DR EMBL; Z86099; CAB06704.1; -; Genomic_DNA.
DR PIR; JQ1500; WMBEXC.
DR RefSeq; YP_009137209.1; NC_001798.2.
DR SMR; P28282; -.
DR BioGRID; 1677950; 2.
DR ELM; P28282; -.
DR PRIDE; P28282; -.
DR DNASU; 1487345; -.
DR GeneID; 1487345; -.
DR KEGG; vg:1487345; -.
DR Proteomes; UP000001874; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007620; Herpes_UL56.
DR Pfam; PF04534; Herpes_UL56; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Host Golgi apparatus; Host membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..235
FT /note="Protein UL56"
FT /id="PRO_0000116125"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 23..26
FT /note="PPXY motif"
FT /evidence="ECO:0000250|UniProtKB:P10240"
FT MOTIF 49..52
FT /note="PPXY motif"
FT /evidence="ECO:0000250|UniProtKB:P10240"
FT MOTIF 144..147
FT /note="PPXY motif"
FT /evidence="ECO:0000250|UniProtKB:P10240"
SQ SEQUENCE 235 AA; 24715 MW; FABB671E49610BC0 CRC64;
MALGAGHAHA CRDDGDDSVI DAPPPYESVA GASAGQFVVI DIDTPTDSPP PYSAGTSPVG
LVSPASSGDG EVCERGRSRR AAWRAARRAR RRAERRARRR SFGPGGLFVE TPLFLPETMI
GAHPGVGGDL PSGLPTYAEA TSDRPPTYAM VMAACPTEPP GGSVGPADQP RVQSSRTWRP
PLVNSRELYR AQRAARCASS SDTPQAPGWC GGTCRHAVFG VVAVVVVIIL AFLWR
