ID   UL76_HCMVA              Reviewed;         325 AA.
AC   P16725; Q7M6L6;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   23-FEB-2022, entry version 62.
DE   RecName: Full=Protein UL76;
GN   Name=UL76;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=10993928; DOI=10.1099/0022-1317-81-10-2407;
RA   Wang S.K., Duh C.Y., Chang T.T.;
RT   "Cloning and identification of regulatory gene UL76 of human
RT   cytomegalovirus.";
RL   J. Gen. Virol. 81:2407-2416(2000).
RN   [4]
RP   ERRATUM OF PUBMED:10993928.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [5]
RP   VIRION.
RX   PubMed=15331708; DOI=10.1128/jvi.78.18.9750-9762.2004;
RA   Wang S.K., Duh C.Y., Wu C.W.;
RT   "Human cytomegalovirus UL76 encodes a novel virion-associated protein that
RT   is able to inhibit viral replication.";
RL   J. Virol. 78:9750-9762(2004).
RN   [6]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=18617993; DOI=10.1371/journal.ppat.1000100;
RA   Salsman J., Zimmerman N., Chen T., Domagala M., Frappier L.;
RT   "Genome-wide screen of three herpesviruses for protein subcellular
RT   localization and alteration of PML nuclear bodies.";
RL   PLoS Pathog. 4:E1000100-E1000100(2008).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL76 supposedly acts on this process through
CC       its effect on host nucleoli. Induces cell cycle arrest in host cells at
CC       the G2/M phase following by apoptosis. The mechanism involves the
CC       inhibition of host mitotic complex cyclinB/CDK1.
CC       {ECO:0000269|PubMed:18617993}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:15331708}. Host
CC       nucleus {ECO:0000269|PubMed:10993928, ECO:0000269|PubMed:18617993}.
CC       Host nucleus, host nucleolus {ECO:0000269|PubMed:18617993}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35391.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00172.1; -; Genomic_DNA.
DR   PIR; S09839; QQBEB4.
DR   IntAct; P16725; 2.
DR   MINT; P16725; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host G2/M cell cycle arrest by virus; Host nucleus; Host-virus interaction;
KW   Late protein; Modulation of host cell cycle by virus; Reference proteome;
KW   Virion.
FT   CHAIN           1..325
FT                   /note="Protein UL76"
FT                   /id="PRO_0000115992"
FT   REGION          222..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..266
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  36069 MW;  5BCD72EC8E8F9BF9 CRC64;
     MPSGRGDDAD STGNALRRLP HVRKRIGKRK HLDIYRRLLR VFPSFVALNR LLGGLFPPEL
     QKYRRRLFIE VRLSRRIPDC VLVFLPPDSG SRGIVYCYVI EFKTTYSDAD DQSVRWHATH
     SLQYAEGLRQ LKGALVDFDF LRLPRGGGQV WSVVPSLVFF QQKADRPSFY RAFRSGRFDL
     CTDSVLDYLG RRQDESVAHL LAATRRRLLR TARGKRAALP RARASAVAGG RGGDNARRGL
     ARGRAHGPGA QTVSASGAQG SGSQGADLLR GSRRARVRGG GAVEPAVRAR RRTVAADAAT
     TTVSSAFFVP RDRRGRSFCR PTRSL