ID   UL76_HCMVM              Reviewed;         325 AA.
AC   Q6SW66; D2K3N4;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 48.
DE   RecName: Full=Protein UL76;
GN   Name=UL76;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   FUNCTION.
RX   PubMed=19526192; DOI=10.1007/s00705-009-0420-y;
RA   Nascimento R., Dias J.D., Parkhouse R.M.;
RT   "The conserved UL24 family of human alpha, beta and gamma herpesviruses
RT   induces cell cycle arrest and inactivation of the cyclinB/cdc2 complex.";
RL   Arch. Virol. 154:1143-1149(2009).
CC   -!- FUNCTION: May participate in nuclear egress of viral particles. Plays a
CC       role in the dispersal of several host nucleolar proteins including
CC       NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively
CC       impact on nuclear egress, UL76 supposedly acts on this process through
CC       its effect on host nucleoli (By similarity). Induces cell cycle arrest
CC       in host cells at the G2/M phase following by apoptosis. The mechanism
CC       involves the inhibition of host mitotic complex cyclinB/CDK1.
CC       {ECO:0000250, ECO:0000269|PubMed:19526192}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}. Host
CC       nucleus, host nucleolus {ECO:0000250}. Host Golgi apparatus
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed late in the infection cycle.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL24 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31628.1; -; Genomic_DNA.
DR   RefSeq; YP_081524.1; NC_006273.2.
DR   BioGRID; 1677989; 2.
DR   PRIDE; Q6SW66; -.
DR   DNASU; 3077435; -.
DR   GeneID; 3077435; -.
DR   KEGG; vg:3077435; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR002580; Herpes_UL24.
DR   Pfam; PF01646; Herpes_UL24; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host G2/M cell cycle arrest by virus; Host Golgi apparatus;
KW   Host nucleus; Host-virus interaction; Late protein;
KW   Modulation of host cell cycle by virus; Reference proteome; Virion.
FT   CHAIN           1..325
FT                   /note="Protein UL76"
FT                   /id="PRO_0000416720"
FT   REGION          222..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  35964 MW;  AAFCDBFB0D97ACA0 CRC64;
     MPSGCGDDAD STGNALRRLP HVRKRIGKRK HLDIYRRLLR VFPSFVALNR LLGGLFPPEL
     QKYRRRLFIE VRLSRRIPDC VLVFLPPDSG SRGIVYCYVI EFKTTYSDAD DQSVRWHATH
     SLQYAEGLRQ LKGALVDFDF LRLPRGGGQV WSVVPSLVFF QQKADRPSFY RAFRSGRFDL
     CTDSVLDYLG RRQDESVAHL LAATRRRLLR AARGKRAALP RARASAVAGG RGGGNARRGL
     ARGRAHGPGA QTVSASGAEG SGSQGTDLLR GSRRARVRGG GAVEPAVRAR RRTVAADAAT
     TTVSSAFVVP RDRRGRSFRR PTRSL