ID   UL78_HCMVM              Reviewed;         431 AA.
AC   F5HET1;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 29.
DE   RecName: Full=Protein UL78;
GN   Name=UL78;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   OLIGOMERIZATION, AND SUBCELLULAR LOCATION.
RX   PubMed=22327422; DOI=10.1007/s00705-012-1246-6;
RA   Wagner S., Arnold F., Wu Z., Schubert A., Walliser C., Tadagaki K.,
RA   Jockers R., Mertens T., Michel D.;
RT   "The 7-transmembrane protein homologue UL78 of the human cytomegalovirus
RT   forms oligomers and traffics between the plasma membrane and different
RT   intracellular compartments.";
RL   Arch. Virol. 157:935-949(2012).
RN   [3]
RP   INTERACTION WITH HOST CCR5 AND CXCR4.
RX   PubMed=22496149; DOI=10.1182/blood-2011-08-372516;
RA   Tadagaki K., Tudor D., Gbahou F., Tschische P., Waldhoer M., Bomsel M.,
RA   Jockers R., Kamal M.;
RT   "Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5
RT   and CXCR4 impairing their HIV coreceptor activity.";
RL   Blood 119:4908-4918(2012).
CC   -!- FUNCTION: Acts as a cellular chemokine receptor and may modulate the
CC       host cell migration pattern which is the primary cellular event
CC       initiated by chemokine receptor activation.
CC   -!- SUBUNIT: Oligomerizes. Interacts with host CCR5 and CXCR4.
CC       {ECO:0000269|PubMed:22496149}.
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000269|PubMed:22327422};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:22327422}. Host
CC       endoplasmic reticulum membrane {ECO:0000269|PubMed:22327422}; Multi-
CC       pass membrane protein {ECO:0000269|PubMed:22327422}. Note=Once
CC       localized on the cell surface, UL78 is quickly endocytosed.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY446894; AAR31630.1; -; Genomic_DNA.
DR   RefSeq; YP_081526.1; NC_006273.2.
DR   SMR; F5HET1; -.
DR   PRIDE; F5HET1; -.
DR   DNASU; 3077549; -.
DR   GeneID; 3077549; -.
DR   KEGG; vg:3077549; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; G-protein coupled receptor; Host cell membrane;
KW   Host endoplasmic reticulum; Host membrane; Host-virus interaction;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..431
FT                   /note="Protein UL78"
FT                   /id="PRO_0000418318"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   431 AA;  47357 MW;  34668FE7F908C657 CRC64;
     MSPSVEETTS VTESIMFAIV SFKHMGPFEG YSMSADRAAS DLLIGMFGSV SLVNLLTIIG
     CLWVLRVTRP PVSVMIFTWN LVLSQFFSIL ATMLSKGIML RGALNLSLCR LVLFVDDVGL
     YSTALFFLFL ILDRLSAISY GRDLWHHETR ENAGVALYAV AFAWVLSIVA AVPTAATGSL
     DYRWLGCQIP IQYAAVDLTI KMWFLLGAPM IAVLANVVEL AYSDRRDHVW SYVGRVCTFY
     VTCLMLFVPY YCFRVLRGVL QPASAAGTGF GIMDYVELAT RTLLTMRLGI LPLFIIAFFS
     REPTKDLDDS FDYLVERCQQ SCHGHFVRRL VQALKRAMYS VELAVCYFST SVRDVAEAVK
     KSSSRCYADA TSAAVVVTTT TSEKATLVEH AEGMASEMCP GTTIDVSAES SSVLCTDGEN
     TVASDATVTA L