ID   UL79_HCMVM              Reviewed;         295 AA.
AC   Q6SW63; D2K3N7;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 46.
DE   RecName: Full=Protein UL79;
GN   Name=UL79;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in the expression of late transcripts bridging
CC       viral DNA replication and late gene expression during infection.
CC       Functions concordantly with UL87 to initiate transcription from over
CC       half of all active viral promoters in late infection, without affecting
CC       host transcription. Acts on and binds to viral early-late and late
CC       kinetic-class promoters. {ECO:0000250|UniProtKB:P16752}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P16752}.
CC       Note=Localizes in replication compartments during virus infection.
CC       {ECO:0000250|UniProtKB:P16752}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL79 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31631.1; -; Genomic_DNA.
DR   RefSeq; YP_081527.1; NC_006273.2.
DR   PRIDE; Q6SW63; -.
DR   DNASU; 3077474; -.
DR   GeneID; 3077474; -.
DR   KEGG; vg:3077474; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR004290; Herpes_UL79.
DR   Pfam; PF03049; Herpes_UL79; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..295
FT                   /note="Protein UL79"
FT                   /id="PRO_0000417847"
FT   REGION          243..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..270
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  33831 MW;  451318733F44C54A CRC64;
     MMARDEENPA VPRVRTGKFS FTCANHLILQ ISEKMSRGQP LSSLRLEELK IVRLICVLLF
     HRGLETLLLR ETMNNLGVSD HAVLSRKTPQ PYWPHLYREL RQAFPGLDFE AAVFDETRAA
     RLSQRLCHPR LSGGLLTRFV QRHTGLPVVF PEDLARNGNI LFSLGTLYGH RLFRLAAFFT
     RHWGAEAYEP LIRIICQKMW YFYLIGTGKM RITPDAFDIQ RSRHETGIFT FIMEDYRTFA
     GTLSRHPHRP HPQQQQHHHP GPPHPPLSHP ASSCLSPEAV LAARALHMPT LANDV