ID   UL79_HHV8P              Reviewed;         257 AA.
AC   Q2HRB4;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Protein UL79 homolog;
GN   Name=ORF18;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
RN   [3]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH ORF30.
RX   PubMed=25056896; DOI=10.1128/jvi.00793-14;
RA   Gong D., Wu N.C., Xie Y., Feng J., Tong L., Brulois K.F., Luan H., Du Y.,
RA   Jung J.U., Wang C.Y., Kang M.K., Park N.H., Sun R., Wu T.T.;
RT   "Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for
RT   late gene expression during lytic replication.";
RL   J. Virol. 88:11369-11382(2014).
RN   [4]
RP   FUNCTION, INTERACTION WITH ORF34, AND SUBCELLULAR LOCATION.
RX   PubMed=28336944; DOI=10.1038/s41598-017-00401-7;
RA   Nishimura M., Watanabe T., Yagi S., Yamanaka T., Fujimuro M.;
RT   "Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene
RT   expression and virus production.";
RL   Sci. Rep. 7:329-329(2017).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH ORF30.
RX   PubMed=30305361; DOI=10.1128/jvi.01488-18;
RA   Castaneda A.F., Glaunsinger B.A.;
RT   "The Interaction between ORF18 and ORF30 Is Required for Late Gene
RT   Expression in Kaposi's Sarcoma-Associated Herpesvirus.";
RL   J. Virol. 93:0-0(2019).
CC   -!- FUNCTION: Plays a role in the expression of late transcripts bridging
CC       viral DNA replication and late gene expression during infection.
CC       {ECO:0000269|PubMed:25056896, ECO:0000269|PubMed:28336944,
CC       ECO:0000269|PubMed:30305361}.
CC   -!- SUBUNIT: Interacts with ORF30 (PubMed:25056896, PubMed:30305361).
CC       Interacts with ORF34 (PubMed:28336944). {ECO:0000269|PubMed:25056896,
CC       ECO:0000269|PubMed:28336944, ECO:0000269|PubMed:30305361}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:28336944}. Host
CC       cytoplasm {ECO:0000269|PubMed:28336944}. Note=Localizes in replication
CC       compartments during virus infection. {ECO:0000269|PubMed:28336944}.
CC   -!- DISRUPTION PHENOTYPE: Lytic replication is able to proceed normally
CC       with the expression of immediate-early and early genes as well as viral
CC       lytic DNA synthesis, but expression of viral late genes is severely
CC       impaired resulting in no detectable virion production.
CC       {ECO:0000269|PubMed:30305361}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL79 family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28869.1; -; Genomic_DNA.
DR   RefSeq; YP_001129371.1; NC_009333.1.
DR   PRIDE; Q2HRB4; -.
DR   DNASU; 4961499; -.
DR   GeneID; 4961499; -.
DR   KEGG; vg:4961499; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004290; Herpes_UL79.
DR   Pfam; PF03049; Herpes_UL79; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="Protein UL79 homolog"
FT                   /id="PRO_0000423788"
SQ   SEQUENCE   257 AA;  29287 MW;  19247889069DEC87 CRC64;
     MLGKYVCETE PLSPGLRRLM WRFLQNKNLN TFHAQELRFI HLVLCKMYNF GLNVYLLREA
     TANAGTYDEV VLGRKVPAEV WKLVYDGLEE MGVSSEMLLC EAYRDSLWMH LNDKVGLLRG
     LANYLFHRLG VTHDVRIAPE NLVDGNFLFN LGSVLPCRLL LAAGYCLAFW GSDEHERWVR
     FFAQKLFICY LIVSGRLMPQ RSLLVWASET GYPGPVEAVC RDIRSMYGIR TYAVSGYLPA
     PSEAQLAYLG AFNNNAV