ID   UL84_HCMVM              Reviewed;         587 AA.
AC   F5HB40;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   23-FEB-2022, entry version 24.
DE   RecName: Full=Protein UL84;
GN   Name=UL84;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays an essential role in viral DNA replication. May
CC       participate in the DNA replication initiation by interacting with the
CC       origin of lytic replication, oriLyt and subsequently recruiting other
CC       viral/cellular factors. Additionally, interacts with and shuttles IRS1
CC       viral mRNA from the host nucleus to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase accessory subunit UL44.
CC       Interacts with HCMV major transcription-activating enzyme IE2.
CC       Interacts with host HNRNPK (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Note=Shuttles between host nucleus and cytoplasm. In the
CC       nucleus, colocalizes with UL44 and IE2 in the viral DNA replication
CC       compartments (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL84 protein family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31636.1; -; Genomic_DNA.
DR   RefSeq; YP_081532.1; NC_006273.2.
DR   PRIDE; F5HB40; -.
DR   GeneID; 3077525; -.
DR   KEGG; vg:3077525; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR010436; Herpes_UL84.
DR   Pfam; PF06284; Cytomega_UL84; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..587
FT                   /note="Protein UL84"
FT                   /id="PRO_0000417848"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           161..170
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           229..238
FT                   /note="Nuclear export signal 1 (NES 1)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           360..367
FT                   /note="Nuclear export signal 2 (NES 2)"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        136..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  65478 MW;  C1DDC681EDA0D238 CRC64;
     MPRVDPNLRN RARRPRARRG GGGGVGSNSS RHSGKCRRQR RALSTPPLTF LATTTTTTMM
     GVASTDDDSL LLKTPDELDK HSGSPQTILT LTDKHDIRQP RVHRGTYHLI QLHLDLRPEE
     LRDPFQILLS TPLQLGEANG ESQTAPATSQ EEETAASHEP EKKKEKEEKK EEEDEDDRND
     DRERGILCVV SNEDSDVRPA FSLFPARPGC HILRSVIDQQ LTRMAIVRLS LNLFALRIIT
     PLLKRLPLRR KAAHHTALHD CLALHLPELT FEPTLDINNV TENAASVADT AESTDADLTP
     TLTVRVRHAL CWHRVEGGIS GPRGLTSRIS ARLSETTAKT LGPSVFGRLE LDPNESPPDL
     TLSSLTLYQD GILRFNVTCD RTEAPADPVA FRLRLRRETV RRPFFSDAPL PYFVPPRSGA
     ADEGLEVRVP YELTLKNSHT LRIYRRFYGP YLGVFVPHNR QGLKMPVTVW LPRSWLELTV
     LVSDENGATF PRDALLGRLY FISSKHTLNR GCLSAMTHQV KSTLHSRSTS HSPSQQQLSV
     LGASIALEDL LPMRLASPET EPQDCKLTEN TTEKTSPVTL AMVCGDL