ID   UL84_HCMVT              Reviewed;         587 AA.
AC   P29839;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   02-JUN-2021, entry version 38.
DE   RecName: Full=UL84 protein;
GN   Name=UL84;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1309892; DOI=10.1128/jvi.66.2.1098-1108.1992;
RA   He Y.S., Xu L., Huang E.S.;
RT   "Characterization of human cytomegalovirus UL84 early gene and
RT   identification of its putative protein product.";
RL   J. Virol. 66:1098-1108(1992).
CC   -!- FUNCTION: Plays an essential role in viral DNA replication. May
CC       participate in the DNA replication initiation by interacting with the
CC       origin of lytic replication, oriLyt and subsequently recruiting other
CC       viral/cellular factors. Additionally, interacts with and shuttles IRS1
CC       viral mRNA from the host nucleus to the cytoplasm (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase accessory subunit UL44.
CC       Interacts with HCMV major transcription-activating enzyme IE2.
CC       Interacts with host HNRNPK (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Note=Shuttles between host nucleus and cytoplasm. In the
CC       nucleus, colocalizes with UL44 and IE2 in the viral DNA replication
CC       compartments (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HHV-5 UL84 protein family. {ECO:0000305}.
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DR   EMBL; M81432; AAA45947.1; -; mRNA.
DR   PIR; A41808; WMBETE.
DR   PRIDE; P29839; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010436; Herpes_UL84.
DR   Pfam; PF06284; Cytomega_UL84; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus.
FT   CHAIN           1..587
FT                   /note="UL84 protein"
FT                   /id="PRO_0000116298"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           161..170
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           229..238
FT                   /note="Nuclear export signal 1 (NES 1)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           360..367
FT                   /note="Nuclear export signal 2 (NES 2)"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        136..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  65388 MW;  13C170E41FB3220B CRC64;
     MPRADPNLRN RARRPRARRG GGGGVGSNSS RHSGKCRRQR RALSAPPLTF LATTTTTTMM
     GVASTDDDSL LLKTPDELDK HSGSPQTILT LTDKHDIRQP RVHRGTYHLI QLHLDLRPEE
     LRDPFQILLS TPLQLGEANG ESQTAPATSQ EEETAASHEL EKKKEKEEKK EEEDEDDRND
     DRERGILCVV SNEDSDVRPA FSLFPARPGC HILRSVIDQQ LTRMAIVRLS LNLFALRIIT
     PPLKRVPLRR KAAHHTALHD CMALHLPELT FESTLDINNV TENAASVADA AESTDADLTP
     TLTVRVRHAV CWHRVEGGIS GPRGLTSRIS ARLSETTAKT LGPSVFGRLE LDPNESPPDL
     TLSSLTLYQD GMLRFNVTCD RTEAPADPVA FRLRLRRETV RRPFFSDAPL PYFVPPRSGA
     ADEGLEVRVP YELTLKNSHT LRIYRRFYGP YLGVFVPHNR QGLKMPVTVW LPRSWLELTV
     LVSDENGATF PRDALLGRLY FISSKHTLNR GCLSAMTHQV KSTLHSRSTS HSPSQQQLSV
     LGASIALEDL LPMRLASPET EPQDCKLTEN TTEKTSPVTL AMVCGDL