ID   UL87_EBVB9              Reviewed;         575 AA.
AC   P25215; Q8AZJ6;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   23-FEB-2022, entry version 60.
DE   RecName: Full=TBP-like protein BcRF1;
GN   ORFNames=BcRF1;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   FUNCTION.
RX   PubMed=22457524; DOI=10.1128/jvi.00159-12;
RA   Gruffat H., Kadjouf F., Mariame B., Manet E.;
RT   "The Epstein-Barr virus BcRF1 gene product is a TBP-like protein with an
RT   essential role in late gene expression.";
RL   J. Virol. 86:6023-6032(2012).
CC   -!- FUNCTION: DNA-binding protein that is required for viral late gene
CC       expression. {ECO:0000269|PubMed:22457524}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL87 family. {ECO:0000305}.
CC   -!- CAUTION: Be careful of the possible confusion between BCRF1 with BcRF1.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA24795.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAD53448.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; V01555; CAA24795.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AJ507799; CAD53448.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_401698.1; NC_007605.1.
DR   PRIDE; P25215; -.
DR   DNASU; 3783690; -.
DR   GeneID; 3783690; -.
DR   KEGG; vg:3783690; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR004285; Herpes_UL87_C.
DR   Pfam; PF03043; Herpes_UL87; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Viral transcription.
FT   CHAIN           1..575
FT                   /note="TBP-like protein BcRF1"
FT                   /id="PRO_0000116229"
FT   REGION          153..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   575 AA;  64304 MW;  79B3206D8DEB7337 CRC64;
     MLAHLNQVTR IPPCPPFSGR EARLKFHFFS WSTFMLSWPN NATLREIRTR AATNLTHHPH
     LVDTLYHASP QTPFLTRSGA LYRFVTCCNC TLPNISIQQC KAGDRPGDLE IILQSNGGGR
     PASFQFPSSP TGSLLRCIVA ASLLPEVSVG HQELSPLRSR SQGGQTDVRS GPDPARRLVA
     LLRREDGAPK DPPLGPFGHP RGPGPAKSED EESERRDAPP PPLDSSFQAS RLVPVGPGFR
     LLVFNTNRVI NTKLVCSEPL VKMRVCNVPR LINNFVARKY VVKETAFTVS LFFTDGVGAN
     LAINVNISGT YLSFLLAMTS LRCFLPVEAI YPAAVSNWNS TLDLHGLENQ SLVRENRSGV
     FWTTNFPSVV SCRDGLNVSW FKAATATISR VHGQTLEQHL IREITPIVTH REAKISRIKN
     RLFTLLELRN RSQIQVLHKR FLEGLLDCAS LLRLDPSCIN RIASEGLFDF SKRSIAHSKN
     RHECALLGHR HSANVTKLVV NERKTRLDIL GRNANFLTRC KHQVNLRQSP IFLTLLRHIR
     RRLGLGRASV KREITLLLAH LRKKTAPIHC RDAQV