ID   UL87_HCMVA              Reviewed;         941 AA.
AC   P16730; Q7M6K4;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Protein UL87;
GN   Name=UL87;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=34339482; DOI=10.1371/journal.ppat.1009796;
RA   Li M., Hu Q., Collins G., Parida M., Ball C.B., Price D.H., Meier J.L.;
RT   "Cytomegalovirus late transcription factor target sequence diversity
RT   orchestrates viral early to late transcription.";
RL   PLoS Pathog. 17:e1009796-e1009796(2021).
CC   -!- FUNCTION: Functions concordantly with UL87 to initiate transcription
CC       from over half of all active viral promoters in late infection, without
CC       affecting host transcription. Acts on and binds to viral early-late and
CC       late kinetic-class promoters. {ECO:0000269|PubMed:34339482}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:34339482}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL87 family. {ECO:0000305}.
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DR   EMBL; X17403; CAA35361.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00184.1; -; Genomic_DNA.
DR   PIR; S09851; S09851.
DR   PRIDE; P16730; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004285; Herpes_UL87_C.
DR   InterPro; IPR007618; Herpes_UL87_N.
DR   Pfam; PF04532; DUF587; 1.
DR   Pfam; PF03043; Herpes_UL87; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host nucleus; Reference proteome.
FT   CHAIN           1..941
FT                   /note="Protein UL87"
FT                   /id="PRO_0000116231"
FT   REGION          482..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          910..941
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        37
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        591
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        661
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        801
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   941 AA;  104804 MW;  4725FF3604BA2814 CRC64;
     MAGAAPRRLG CDALIVVGGS AMPRRVLHVP VHVRACNLTQ ELSTGEDARF CRPRPVNVER
     VRAVFAALYR ACPIHVRTEP ERVKLVLGRL LLGPVAVPCF CDGEVEGHGE HLVPTTQFCR
     GPLLYVHRRC CCGSVTAGRA LSYHVLENHV ATHVLRGLLS LTEWNRELPS LFCDCPGGGG
     ASGTEERYAM ACLPRDLSLH LDDYPYLMVE IGRVLSVSEV DDYVTAVSGY LGEAAAPRIQ
     VHYKLLFGLN VRPQAPCALD ATRDFFLLEL QKLWLGVEYH HEVTSEFFGR VLAQLHRDRA
     RVMMALRLPE QTVCHLSTFV LSRFKRQVLY FKLQVSYGKC RTGHADRSGG GGNGGNQGHH
     NLLCYRRLSV TFADTDTVWR NLFYVYYELA RDLGSHGTED RPVSRGYGVS CASRTSRLSP
     SESTVVSANG HALSSTALPT TSAGHKLSLP RDPAADRVRR YVCIISRLMY ARYGERWRKH
     CQRRSETGEE EEEETLESGE TDATPPFDFT GQQLRRAYQE HRRRKHLAVQ RYAPCRRKLI
     GGMEFAEVTG VSLDRIAVNA FNTNRVINMK AALSSIAASG LGVRAPRLPK NMTHSFVMYK
     HTFKEPACTV STFVSNDAVY INSLNVNIRG SYPEFLYSLG VYRLHVNIDH FFLPAVVCNS
     NSSLDVHGLE DQAVIRSERS KVYWTTNFPC MISHTNNVNV GWFKAATAIV PRVSGADLEA
     ILLKELSCIK NMRDVCIDYG LHRVFTQLEL RNSYQIPFLA KQLVLFLRAC LLKLHGREKR
     LQLDRLVFEA AQRGLFDYSK NLTAHTKIKH TCALIGSRLA NNVPKILARN KKVKLDHLGR
     NANVLTVCRH VEAHKIPRTR LKVLVEVLGA LQSISGTPHT REVIHQTLFR LCSAAAATSG
     LCSSPPPLCV SSSSSVPSVP TSVSVDGSSE PTSPRARFAS R