ID   UL87_HCMVM              Reviewed;         941 AA.
AC   Q6SW55; D2K3P5;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Uncharacterized protein UL87;
GN   Name=UL87;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Functions concordantly with UL87 to initiate transcription
CC       from over half of all active viral promoters in late infection, without
CC       affecting host transcription. Acts on and binds to viral early-late and
CC       late kinetic-class promoters. {ECO:0000250|UniProtKB:P16730}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250|UniProtKB:P16730}.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL87 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31639.1; -; Genomic_DNA.
DR   RefSeq; YP_081535.1; NC_006273.2.
DR   BioGRID; 1678018; 12.
DR   PRIDE; Q6SW55; -.
DR   GeneID; 3077465; -.
DR   KEGG; vg:3077465; -.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004285; Herpes_UL87_C.
DR   InterPro; IPR007618; Herpes_UL87_N.
DR   Pfam; PF04532; DUF587; 1.
DR   Pfam; PF03043; Herpes_UL87; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..941
FT                   /note="Uncharacterized protein UL87"
FT                   /id="PRO_0000418288"
FT   REGION          479..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          910..941
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  104949 MW;  87A544B382475D25 CRC64;
     MAGAAPRRLG CDALIVVGGS AMPRRVLHVP VHVRACNLTQ ELSTGEDARF CRPRPVNVER
     VRAVFAALYR ACPIHVRTEP ERVKLVLGRL LLGPVAVPCF CDGEVEGHGE HLVPTTQFCR
     GPLLYVHRRC CCGSVTAGRA LSYHVLENHV ATHVLRGLLS LTEWNRELPS LFCDCPGGGG
     ASGTEERYAM ACLPRDLSLH LDDYPYLMVE IGRVLSVSEV DDYVTAVSGY LGEAAAPRIQ
     VHYKLLFGLN VRPQAPCALD ATRDFFLLEL QKLWLGVEYH HEVTSEFFGR VLAQLHRDRA
     RVMMALRLPE QTVCHLSTFV LSRFKRQVLY FKLQVSYGKC RTGHADRSGG GGNGGNQGHH
     NLLCYRRLSV TFADTDTVWR NLFYVYYELA RDLGSHGTEN RPVNRGYGVS CAPRTSRLSP
     SESTVVSANG HALSSTALPT TSAGHKLSLP RDPAADRVRR YVCIISRLMY ARYGERWRKH
     RQRRSETGEE EEEETLESGE TDATPPFDFT GQQLRRAYQE HRRRKHLAVQ RYAPCRRKLI
     GGMEFAEVTG VSLDRIAVNA FNTNRVINMK AALSSIAASG LGVRAPRLPK NMTHSFVMYK
     HTFKEPACTV STFVSNDAVY INSLNVNIRG SYPEFLYSLG VYRLHVNIDH FFLPAVVCNS
     NSSLDVHGLE DQAVIRSERS KVYWTTNFPC MISHTNNVNV GWFKAATAIV PRVSGADLEA
     ILLKELSCIK NMRDVCIDYG LHRVFTQLEL RNSYQIPFLA KQLVLFLRAC LLKLHGREKR
     LQLDRLVFEA AQRGLFDYSK NLTAHTKIKH TCALIGSRLA NNVPKILARN KKVKLDHLGR
     NANVLTVCRH VEAHKIPRTR LKVLVEVLGV LQSISGTPHT REVIHQTLFR LCSAAAATSG
     LCSSPPPLCV SSSSSVPSVP TSVSVDGSSE PTSPRVRFAS R