ID   UL88_HCMVA              Reviewed;         429 AA.
AC   P16731; Q7M6K3;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein UL88;
GN   Name=UL88;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2161319; DOI=10.1007/978-3-642-74980-3_6;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [2]
RP   GENOME REANNOTATION.
RX   PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the chimpanzee
RT   cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [3]
RP   ERRATUM OF PUBMED:12533697.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J.,
RA   McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=15452216; DOI=10.1128/jvi.78.20.10960-10966.2004;
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RT   "Identification of proteins in human cytomegalovirus (HCMV) particles: the
RT   HCMV proteome.";
RL   J. Virol. 78:10960-10966(2004).
RN   [5]
RP   ERRATUM OF PUBMED:15452216.
RA   Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J.,
RA   Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W.,
RA   Shenk T., Smith R.D., Nelson J.A.;
RL   J. Virol. 78:13395-13395(2004).
RN   [6]
RP   INTERACTION WITH UL48.
RX   PubMed=20962080; DOI=10.1128/jvi.01551-10;
RA   Phillips S.L., Bresnahan W.A.;
RT   "Identification of binary interactions between human cytomegalovirus virion
RT   proteins.";
RL   J. Virol. 85:440-447(2011).
RN   [7]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=32376624; DOI=10.1128/jvi.00474-20;
RA   Kumar R., Cruz L., Sandhu P.K., Buchkovich N.J.;
RT   "UL88 Mediates the Incorporation of a Subset of Proteins into the Virion
RT   Tegument.";
RL   J. Virol. 94:0-0(2020).
CC   -!- FUNCTION: Plays a role in incorporating a subset of tegument proteins
CC       into the virion. {ECO:0000269|PubMed:32376624}.
CC   -!- SUBUNIT: Interacts with UL48. {ECO:0000269|PubMed:20962080}.
CC   -!- SUBCELLULAR LOCATION: Virion. Virion tegument
CC       {ECO:0000269|PubMed:32376624}. Host cytoplasm
CC       {ECO:0000269|PubMed:32376624}. Note=Accumulates in a juxtanuclear
CC       location reminiscent of the viral cytoplasmic assembly compartment.
CC       {ECO:0000269|PubMed:32376624}.
CC   -!- INDUCTION: Expressed during the late times of infection.
CC       {ECO:0000269|PubMed:32376624}.
CC   -!- SIMILARITY: Belongs to the herpesviridae U59/UL88 family.
CC       {ECO:0000305}.
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DR   EMBL; X17403; CAA35362.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00185.1; -; Genomic_DNA.
DR   PIR; S09852; S09852.
DR   RefSeq; YP_081536.1; NC_006273.2.
DR   BioGRID; 1678062; 1.
DR   DNASU; 3077509; -.
DR   GeneID; 3077509; -.
DR   KEGG; vg:3077509; -.
DR   Proteomes; UP000008991; Genome.
DR   Proteomes; UP000008992; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007616; Herpes_U59/UL88.
DR   Pfam; PF04529; Herpes_U59; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..429
FT                   /note="Protein UL88"
FT                   /id="PRO_0000116234"
SQ   SEQUENCE   429 AA;  47689 MW;  9D1AAA685AAABD08 CRC64;
     MMEAAAAAAA AFRPEERPTP GWHDAALLMD DGTVREHAFR NGPLSQLIRR VLPPPPDAED
     DVVFASELCF YCSGRFNRRS SVFSIYWQKH SDLVYALTGI THCAKLVVEC GQLGSSRLRW
     RDGDASGEER RGDDDSRDEL YDVPGIYMIR VNDGGSTGPR HVIWPGTSVL WAPDVVITTV
     QRRISAARAL VNTFRQYFFL LERRSHEELV LCPPEMEERL APLLQSATRG DSDMFDGVVA
     SAYHRLRMSN IPRSSARLLE HCVGLAGAKK LLLLDVPRLE NYFLCQVCLY ELDEDEMGEE
     MLGMLAGKPE DAAVSGASGG FLLHRKTMKL AACLCLLLNS LHLHQEALEA LDPPPPRVEE
     NDLVNVVLRR YYRSHGGVQA RTLAAARALL ADYAETFSPL GSFTRLGYDR LVSADAGVSR
     RHLVALLRA