ID   UL88_HCMVM              Reviewed;         429 AA.
AC   F5H9F9;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Protein UL88;
GN   Name=UL88;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Plays a role in incorporating a subset of tegument proteins
CC       into the virion. {ECO:0000250|UniProtKB:P16731}.
CC   -!- SUBUNIT: Interacts with UL48. {ECO:0000250|UniProtKB:P16731}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P16731}. Virion
CC       tegument {ECO:0000250|UniProtKB:P16731}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:P16731}. Note=Accumulates in a juxtanuclear
CC       location reminiscent of the viral cytoplasmic assembly compartment.
CC       {ECO:0000250|UniProtKB:P16731}.
CC   -!- SIMILARITY: Belongs to the herpesviridae U59/UL88 family.
CC       {ECO:0000305}.
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DR   EMBL; AY446894; AAR31640.1; -; Genomic_DNA.
DR   RefSeq; YP_081536.1; NC_006273.2.
DR   BioGRID; 1678062; 1.
DR   DNASU; 3077509; -.
DR   GeneID; 3077509; -.
DR   KEGG; vg:3077509; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0072517; C:host cell viral assembly compartment; TAS:Reactome.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   InterPro; IPR007616; Herpes_U59/UL88.
DR   Pfam; PF04529; Herpes_U59; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..429
FT                   /note="Protein UL88"
FT                   /id="PRO_0000418289"
SQ   SEQUENCE   429 AA;  47689 MW;  9D1AAA685AAABD08 CRC64;
     MMEAAAAAAA AFRPEERPTP GWHDAALLMD DGTVREHAFR NGPLSQLIRR VLPPPPDAED
     DVVFASELCF YCSGRFNRRS SVFSIYWQKH SDLVYALTGI THCAKLVVEC GQLGSSRLRW
     RDGDASGEER RGDDDSRDEL YDVPGIYMIR VNDGGSTGPR HVIWPGTSVL WAPDVVITTV
     QRRISAARAL VNTFRQYFFL LERRSHEELV LCPPEMEERL APLLQSATRG DSDMFDGVVA
     SAYHRLRMSN IPRSSARLLE HCVGLAGAKK LLLLDVPRLE NYFLCQVCLY ELDEDEMGEE
     MLGMLAGKPE DAAVSGASGG FLLHRKTMKL AACLCLLLNS LHLHQEALEA LDPPPPRVEE
     NDLVNVVLRR YYRSHGGVQA RTLAAARALL ADYAETFSPL GSFTRLGYDR LVSADAGVSR
     RHLVALLRA