ID   CA171_CONPO             Reviewed;          70 AA.
AC   P0DUQ6;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   25-MAY-2022, entry version 3.
DE   RecName: Full=Conotoxin Pl171 {ECO:0000303|PubMed:26506909};
DE   Flags: Precursor;
OS   Conus planorbis (Planorbis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=97183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-69, SUBCELLULAR
RP   LOCATION, AND AMIDATION AT PHE-69.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=26506909; DOI=10.1002/pmic.201500220;
RA   Jin A.H., Vetter I., Himaya S.W., Alewood P.F., Lewis R.J., Dutertre S.;
RT   "Transcriptome and proteome of Conus planorbis identify the nicotinic
RT   receptors as primary target for the defensive venom.";
RL   Proteomics 15:4030-4040(2015).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26506909}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:26506909}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha5/5 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:26506909"
FT   CHAIN           22..69
FT                   /note="Conotoxin Pl171"
FT                   /evidence="ECO:0000269|PubMed:26506909"
FT                   /id="PRO_0000453214"
FT   MOD_RES         69
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:26506909"
FT   DISULFID        54..61
FT                   /evidence="ECO:0000250|UniProtKB:P69657"
FT   DISULFID        55..67
FT                   /evidence="ECO:0000250|UniProtKB:P69657"
SQ   SEQUENCE   70 AA;  7787 MW;  F996477B0912B18F CRC64;
     MGMRMMFTMI LLVVLVTTVV SFTLDRVLGP VSDGRNAAPD DEKFDRMEYF LSKCCANPST
     CDLSLLCIFG