ID   UL95_HCMVM              Reviewed;         533 AA.
AC   Q6SW48; D2K3Q2;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 48.
DE   RecName: Full=Protein UL95;
GN   Name=UL95;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Participates in the expression of late viral mRNAs. Expressed
CC       before viral DNA replication, UL95 assembles at the viral pre-
CC       replication complexes (pre-RCs) containing the early viral protein
CC       UL44.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Recruited to nuclear
CC       replication compartments.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL95 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31646.1; -; Genomic_DNA.
DR   RefSeq; YP_081542.1; NC_006273.2.
DR   PRIDE; Q6SW48; -.
DR   GeneID; 3077502; -.
DR   KEGG; vg:3077502; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004280; Herpes_UL95.
DR   Pfam; PF03038; Herpes_UL95; 1.
PE   3: Inferred from homology;
KW   Early protein; Host nucleus; Reference proteome.
FT   CHAIN           1..533
FT                   /note="Protein UL95"
FT                   /id="PRO_0000417851"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   533 AA;  57273 MW;  C0B150143432FD4E CRC64;
     MMAAAVVRAE VRRQRREERK KMASARTTED PPENHVVADV ACGTGAVTRS SSSSLVVSSS
     SASGSDESSS ASPLSFPVSS PSTAVRSPGS AGVSTSLCSV ERMVELSAQS PAADFSVSEA
     WRFEEAVNMA LVACEAVSPY DRFRLIETPD ENFLLVTNVI PRESAEVPVL DSSSSGGDSG
     PEDKKKNVGN KTAGEKNGGG SRAKRRRRRR APKNDAATPS FLRRHDVLER FAAAAEPLPS
     LCVHDYALRN ADRVTYDGEL IYGSYLLYRK AHVELSLSSN KVQHVEAVLR QVYTPGLLDH
     HNVCDVEALL WLLYCGPRSF CARDTCFGRE KNGCPFPALL PKLFYEPVRD YMTYMNLAEL
     YVFVWYRGYE FPAPTPQATT AGGGGGGGSG GGGGAGACAV ETSASAGRVD DAGDEVHLPL
     KPVSLDRLRE VLQAVRGRFS GREVPAWPAS SRTCLLCALY SQNRLCLDLA RDEARTVSYS
     PIVIQDCAAA VTDVTLSHIL PGQSTVSLFP VYHVGKLLDA LSLNDAGLIT LNL