ID   UL95_HCMVT              Reviewed;         527 AA.
AC   B9VXQ2;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   02-JUN-2021, entry version 25.
DE   RecName: Full=Protein UL95;
GN   Name=UL95;
OS   Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10363;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19553388; DOI=10.1099/vir.0.013250-0;
RA   Bradley A.J., Lurain N.S., Ghazal P., Trivedi U., Cunningham C.,
RA   Baluchova K., Gatherer D., Wilkinson G.W., Dargan D.J., Davison A.J.;
RT   "High-throughput sequence analysis of variants of human cytomegalovirus
RT   strains Towne and AD169.";
RL   J. Gen. Virol. 90:2375-2380(2009).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=21507978; DOI=10.1128/jvi.00384-11;
RA   Isomura H., Stinski M.F., Murata T., Yamashita Y., Kanda T., Toyokuni S.,
RA   Tsurumi T.;
RT   "The human cytomegalovirus gene products essential for late viral gene
RT   expression assemble into prereplication complexes before viral DNA
RT   replication.";
RL   J. Virol. 85:6629-6644(2011).
CC   -!- FUNCTION: Participates in the expression of late viral mRNAs. Expressed
CC       before viral DNA replication, UL95 assembles at the viral pre-
CC       replication complexes (pre-RCs) containing the early viral protein
CC       UL44. {ECO:0000269|PubMed:21507978}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:21507978}.
CC       Note=Recruited to nuclear replication compartments.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL95 family. {ECO:0000305}.
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DR   EMBL; FJ616285; ACM48072.1; -; Genomic_DNA.
DR   Proteomes; UP000006907; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004280; Herpes_UL95.
DR   Pfam; PF03038; Herpes_UL95; 1.
PE   3: Inferred from homology;
KW   Early protein; Host nucleus.
FT   CHAIN           1..527
FT                   /note="Protein UL95"
FT                   /id="PRO_0000417850"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   527 AA;  56959 MW;  ED22D6A0AEE5A13C CRC64;
     MMAAAVVRAE VRRQRREERK KMAAARTTED PPENHVVADV ACGTGAVTRS SSSSLVVSSS
     SASGSDEPSS ASPLSFPVCS PSTAVRSPGS AGVSTSLCSV ERMVELSAQS PAADFSVSEA
     WRFEEAVNMA LVACEAVSPY DRFRLIETPD ENFLLVTNVI PRESAEVPVL DSSSSGGDSG
     PEDKKKNVGN KTAGEKNGGG SRAKRRRRRR APKNDAATPS FLRRHDVLER FAAAAEPLPS
     LCVRDYALRN ADRVTYDGEL IYGSYLLYRK AHVELSLSSN KVQHVEAVLR QVYTPGLLDH
     HNVCDVEALL WLLYCGPRSF CARDTCFGRE KNGCPFPALL PKLFYEPVRD YMTYMNLAEL
     YVFVWYRGYE FPAPTPQATT AGSGGGGGAG ACAVETSASA GRVDDAGDEV HLPLKPVSLD
     RLREVLQAVR GRFSGREVPA WPASSRTCLL CALYSQNRLC LDLARDEART VSYSPIVIQD
     CAAAVTDVTL SHILPGQSTV SLFPVYHVGK LLDALSLNDA GLITLNL