CA174_DANRE
ID CA174_DANRE Reviewed; 189 AA.
AC Q1L9C7; A5PL76; A8KBU8; Q1L9C8;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=UPF0688 protein C1orf174 homolog;
GN ORFNames=si:ch211-147a11.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1L9C7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1L9C7-2; Sequence=VSP_036165;
CC -!- SIMILARITY: Belongs to the UPF0688 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI54252.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR352301; CAK04132.1; -; Genomic_DNA.
DR EMBL; CR352301; CAK04133.1; -; Genomic_DNA.
DR EMBL; BC142775; AAI42776.1; -; mRNA.
DR EMBL; BC154251; AAI54252.1; ALT_INIT; mRNA.
DR RefSeq; NP_001038302.1; NM_001044837.1. [Q1L9C7-2]
DR RefSeq; XP_005166959.1; XM_005166902.2. [Q1L9C7-1]
DR AlphaFoldDB; Q1L9C7; -.
DR STRING; 7955.ENSDARP00000090818; -.
DR PaxDb; Q1L9C7; -.
DR PRIDE; Q1L9C7; -.
DR Ensembl; ENSDART00000100046; ENSDARP00000090818; ENSDARG00000069009. [Q1L9C7-1]
DR Ensembl; ENSDART00000140978; ENSDARP00000120453; ENSDARG00000069009. [Q1L9C7-2]
DR GeneID; 795658; -.
DR KEGG; dre:795658; -.
DR ZFIN; ZDB-GENE-060503-102; si:ch211-147a11.3.
DR eggNOG; ENOG502SANK; Eukaryota.
DR GeneTree; ENSGT00390000016496; -.
DR HOGENOM; CLU_1626472_0_0_1; -.
DR InParanoid; Q1L9C7; -.
DR OMA; RHYYAKE; -.
DR OrthoDB; 1278407at2759; -.
DR TreeFam; TF336079; -.
DR PRO; PR:Q1L9C7; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000069009; Expressed in cleaving embryo and 29 other tissues.
DR ExpressionAtlas; Q1L9C7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR031530; UPF0688.
DR PANTHER; PTHR28491; PTHR28491; 2.
DR Pfam; PF15772; UPF0688; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..189
FT /note="UPF0688 protein C1orf174 homolog"
FT /id="PRO_0000359759"
FT REGION 53..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 6..31
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036165"
FT CONFLICT 35
FT /note="K -> R (in Ref. 2; AAI42776)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="S -> L (in Ref. 2; AAI42776)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="E -> D (in Ref. 2; AAI42776)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 20784 MW; 37A60E9A572F8114 CRC64;
MRAKQTVVVS LGQRVCGAVS LNPPGVKSSV KKAAKRRVLL QRSAPDIARA VRQMAGDGGE
AKRLPKRPFH GEVEENSSAA VDGNVKIQPG KKAPGERRGK ENSAAKCTGL TSGSAEAKME
QSVHGSQTTD PSVFFDEDSN HVFPVEQFFG NLDVVEDYPR RTPGSKRMTR REYRSMHYYA
KEDSEEEHL
