CA174_MOUSE
ID CA174_MOUSE Reviewed; 230 AA.
AC Q80WR5; A2AM12; Q8CA21;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=UPF0688 protein C1orf174 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPF0688 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM18763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK039812; BAC30459.1; -; mRNA.
DR EMBL; AL806525; CAM18763.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL806525; CAM18764.1; -; Genomic_DNA.
DR EMBL; BC052148; AAH52148.1; -; mRNA.
DR CCDS; CCDS19003.1; -.
DR RefSeq; NP_001156491.1; NM_001163019.1.
DR RefSeq; NP_780496.2; NM_175287.4.
DR AlphaFoldDB; Q80WR5; -.
DR STRING; 10090.ENSMUSP00000054638; -.
DR iPTMnet; Q80WR5; -.
DR PhosphoSitePlus; Q80WR5; -.
DR EPD; Q80WR5; -.
DR jPOST; Q80WR5; -.
DR MaxQB; Q80WR5; -.
DR PaxDb; Q80WR5; -.
DR PeptideAtlas; Q80WR5; -.
DR PRIDE; Q80WR5; -.
DR Antibodypedia; 2157; 63 antibodies from 14 providers.
DR Ensembl; ENSMUST00000058393; ENSMUSP00000054638; ENSMUSG00000047613.
DR GeneID; 97159; -.
DR KEGG; mmu:97159; -.
DR UCSC; uc008wau.2; mouse.
DR MGI; MGI:2140680; A430005L14Rik.
DR VEuPathDB; HostDB:ENSMUSG00000047613; -.
DR eggNOG; ENOG502SANK; Eukaryota.
DR GeneTree; ENSGT00390000016496; -.
DR HOGENOM; CLU_096286_0_0_1; -.
DR InParanoid; Q80WR5; -.
DR OMA; ARTVCQT; -.
DR OrthoDB; 1610051at2759; -.
DR PhylomeDB; Q80WR5; -.
DR TreeFam; TF336079; -.
DR BioGRID-ORCS; 97159; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q80WR5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80WR5; protein.
DR Bgee; ENSMUSG00000047613; Expressed in spermatocyte and 250 other tissues.
DR ExpressionAtlas; Q80WR5; baseline and differential.
DR Genevisible; Q80WR5; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR031530; UPF0688.
DR PANTHER; PTHR28491; PTHR28491; 1.
DR Pfam; PF15772; UPF0688; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..230
FT /note="UPF0688 protein C1orf174 homolog"
FT /id="PRO_0000294245"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 180
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IYL3"
FT CONFLICT 52
FT /note="D -> A (in Ref. 1; BAC30459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 230 AA; 24774 MW; 24D8405562EC2F4F CRC64;
MRSRKLTGGV RSSARLRARS YSSASLASAR DVTSSTSAKT TCLASSSHKA TDRRTSKKFK
YDKGHLVKAE LQKLDPKSDI SSLPKVAPVA PCENKFAEDS AEAAVSVPES REPPQGCSTP
ASEEPSVKAE NGLSTEPSSA AAAQEPDDSS AGQAEPVPRT EEVRASVLQM DSSIFLDDDS
NQPMPVSRFF GNVELMQDLP PASSSYPSMS RREFRKMHFR AKDDEDDAEG
