CA185_HUMAN
ID CA185_HUMAN Reviewed; 199 AA.
AC Q5T7R7; A6NHS3;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Uncharacterized protein C1orf185;
GN Name=C1orf185;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK130995; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL162430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS44142.1; -.
DR RefSeq; NP_001129980.1; NM_001136508.1.
DR AlphaFoldDB; Q5T7R7; -.
DR SMR; Q5T7R7; -.
DR BioGRID; 129898; 1.
DR STRING; 9606.ENSP00000360824; -.
DR BioMuta; C1orf185; -.
DR DMDM; 74745420; -.
DR MassIVE; Q5T7R7; -.
DR PaxDb; Q5T7R7; -.
DR PeptideAtlas; Q5T7R7; -.
DR PRIDE; Q5T7R7; -.
DR ProteomicsDB; 64679; -.
DR Antibodypedia; 66801; 32 antibodies from 4 providers.
DR DNASU; 284546; -.
DR Ensembl; ENST00000371759.7; ENSP00000360824.2; ENSG00000204006.11.
DR GeneID; 284546; -.
DR KEGG; hsa:284546; -.
DR MANE-Select; ENST00000371759.7; ENSP00000360824.2; NM_001136508.2; NP_001129980.1.
DR UCSC; uc001csh.4; human.
DR CTD; 284546; -.
DR DisGeNET; 284546; -.
DR GeneCards; C1orf185; -.
DR HGNC; HGNC:28096; C1orf185.
DR HPA; ENSG00000204006; Tissue enriched (testis).
DR neXtProt; NX_Q5T7R7; -.
DR OpenTargets; ENSG00000204006; -.
DR PharmGKB; PA142672433; -.
DR VEuPathDB; HostDB:ENSG00000204006; -.
DR eggNOG; ENOG502T2P4; Eukaryota.
DR GeneTree; ENSGT00390000000797; -.
DR InParanoid; Q5T7R7; -.
DR OMA; QNLQHNI; -.
DR OrthoDB; 1278761at2759; -.
DR PhylomeDB; Q5T7R7; -.
DR TreeFam; TF338951; -.
DR BioGRID-ORCS; 284546; 12 hits in 1050 CRISPR screens.
DR ChiTaRS; C1orf185; human.
DR GenomeRNAi; 284546; -.
DR Pharos; Q5T7R7; Tdark.
DR PRO; PR:Q5T7R7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T7R7; protein.
DR Bgee; ENSG00000204006; Expressed in left testis and 35 other tissues.
DR ExpressionAtlas; Q5T7R7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031695; DUF4718.
DR PANTHER; PTHR37858; PTHR37858; 1.
DR Pfam; PF15842; DUF4718; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..199
FT /note="Uncharacterized protein C1orf185"
FT /id="PRO_0000271101"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 199 AA; 22411 MW; B70093A39E99B3EC CRC64;
MASPKGFFNY LTYFLAAGAV TLGIGFFALA SALWFLICKR REIFQNSKFK AIDERCRQRP
SMAKIKSHSQ CVFISRNFHT GRFQLQEEQR KKEAAHIKAI KDHSKDEPQL ATKNIICDPS
ETSSTTNRSS VTLSLSTLPS DSYYSQSIEA ADDWFSDDSL VKRNSPMPSL GEPLMEKVFS
YLSTISLEEG TESVLNDTL
