CA185_MOUSE
ID CA185_MOUSE Reviewed; 230 AA.
AC Q9CPZ3; Q9DAM0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Uncharacterized protein C1orf185 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CPZ3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CPZ3-2; Sequence=VSP_022279;
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DR EMBL; AK005726; BAB24207.1; -; mRNA.
DR EMBL; AK015869; BAB30009.1; -; mRNA.
DR EMBL; AK019777; BAB31850.1; -; mRNA.
DR EMBL; BC125547; AAI25548.1; -; mRNA.
DR EMBL; BC125549; AAI25550.1; -; mRNA.
DR CCDS; CCDS18465.1; -. [Q9CPZ3-1]
DR CCDS; CCDS57290.1; -. [Q9CPZ3-2]
DR RefSeq; NP_001186019.1; NM_001199090.1. [Q9CPZ3-2]
DR RefSeq; NP_080567.1; NM_026291.3. [Q9CPZ3-1]
DR AlphaFoldDB; Q9CPZ3; -.
DR SMR; Q9CPZ3; -.
DR STRING; 10090.ENSMUSP00000099786; -.
DR GlyGen; Q9CPZ3; 1 site.
DR PaxDb; Q9CPZ3; -.
DR PRIDE; Q9CPZ3; -.
DR Antibodypedia; 66801; 32 antibodies from 4 providers.
DR Ensembl; ENSMUST00000082306; ENSMUSP00000080923; ENSMUSG00000060491. [Q9CPZ3-2]
DR Ensembl; ENSMUST00000102725; ENSMUSP00000099786; ENSMUSG00000060491. [Q9CPZ3-1]
DR GeneID; 67646; -.
DR KEGG; mmu:67646; -.
DR UCSC; uc008uco.2; mouse. [Q9CPZ3-2]
DR UCSC; uc008ucp.2; mouse. [Q9CPZ3-1]
DR MGI; MGI:1914896; 4930522H14Rik.
DR VEuPathDB; HostDB:ENSMUSG00000060491; -.
DR eggNOG; ENOG502T2P4; Eukaryota.
DR GeneTree; ENSGT00390000000797; -.
DR HOGENOM; CLU_1431188_0_0_1; -.
DR InParanoid; Q9CPZ3; -.
DR OrthoDB; 1278761at2759; -.
DR PhylomeDB; Q9CPZ3; -.
DR TreeFam; TF338951; -.
DR BioGRID-ORCS; 67646; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q9CPZ3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CPZ3; protein.
DR Bgee; ENSMUSG00000060491; Expressed in spermatid and 16 other tissues.
DR Genevisible; Q9CPZ3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031695; DUF4718.
DR PANTHER; PTHR37858; PTHR37858; 1.
DR Pfam; PF15842; DUF4718; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..230
FT /note="Uncharacterized protein C1orf185 homolog"
FT /id="PRO_0000271102"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..5
FT /note="MTSPN -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_022279"
SQ SEQUENCE 230 AA; 25707 MW; E58B166496E38359 CRC64;
MTSPNGVFSH LTYFMAAGAL SLGIGFFALA SALWFLICKR RELFEESKFK EFGENMKQGS
CKPKLKAHPQ CVFISRNFHA GYLQSQTEKR EKEEAEKKAV RSHSKVEFCL QDPISCESPE
VTSVANGSSV STLSLSTSIS SSYCCQTVEE AEDWLTDDCL ETRIPLKNPL LGEPLKKKVL
AYLSSISLEE WPGNTVSNTF CSEQKTDSLK ELLVLKNTEV GKHNLQFDIE
