CA18_CONLE
ID CA18_CONLE Reviewed; 64 AA.
AC A1X8C2;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Alpha-conotoxin-like Lp1.8 {ECO:0000303|PubMed:17400270};
DE AltName: Full=Alpha-conotoxin-like Lp1.7 {ECO:0000312|EMBL:ABD33854.1};
DE Flags: Precursor;
OS Conus leopardus (Leopard cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX NCBI_TaxID=101306;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=17400270; DOI=10.1016/j.toxicon.2007.02.011;
RA Yuan D.-D., Han Y.-H., Wang C.-G., Chi C.-W.;
RT "From the identification of gene organization of alpha conotoxins to the
RT cloning of novel toxins.";
RL Toxicon 49:1135-1149(2007).
CC -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By
CC similarity). Has possibly a distinct nAChR binding mode from other
CC alpha-conotoxins, due to a different three residue motif (Lys-Xaa-Pro
CC instead of the conserved Ser-Xaa-Pro motif) (By similarity).
CC {ECO:0000250|UniProtKB:Q2I2R8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:17400270}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:17400270}.
CC -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
CC -!- CAUTION: There is a discrepancy in nomenclature: was submitted as Lp1.7
CC but is named Lp1.8 in PubMed:17400270. {ECO:0000305|PubMed:17400270}.
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DR EMBL; DQ311062; ABD33854.1; -; mRNA.
DR AlphaFoldDB; A1X8C2; -.
DR SMR; A1X8C2; -.
DR ConoServer; 552; Lp1.8 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR009958; Conotoxin_a-typ.
DR Pfam; PF07365; Toxin_8; 1.
PE 3: Inferred from homology;
KW Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..41
FT /evidence="ECO:0000305|PubMed:17400270"
FT /id="PRO_0000370653"
FT PEPTIDE 42..64
FT /note="Alpha-conotoxin-like Lp1.8"
FT /evidence="ECO:0000305|PubMed:17400270"
FT /id="PRO_0000370654"
FT REGION 49..51
FT /note="Lacks the Ser-Xaa-Pro motif that is crucial for
FT potent interaction with nAChR"
FT /evidence="ECO:0000305"
FT DISULFID 47..53
FT /evidence="ECO:0000250|UniProtKB:P56636"
FT DISULFID 48..61
FT /evidence="ECO:0000250|UniProtKB:P56636"
SQ SEQUENCE 64 AA; 7577 MW; 304BA6FF341B9241 CRC64;
MGMRMMFTMF LLVVLTTTVV SFNSDRESNH ENRRTSNQIT RGVWDECCKD PQCRQNHMQH
CPAR