CA198_MOUSE
ID CA198_MOUSE Reviewed; 322 AA.
AC Q8C3W1; Q3TCS2; Q3U2K7; Q3U3E1; Q6PDM3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Uncharacterized protein C1orf198 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AK084773; BAC39275.1; -; mRNA.
DR EMBL; AK154813; BAE32847.1; -; mRNA.
DR EMBL; AK155222; BAE33133.1; -; mRNA.
DR EMBL; AK170562; BAE41883.1; -; mRNA.
DR EMBL; BC058626; AAH58626.1; -; mRNA.
DR CCDS; CCDS22773.1; -.
DR RefSeq; NP_780358.3; NM_175149.4.
DR AlphaFoldDB; Q8C3W1; -.
DR SMR; Q8C3W1; -.
DR BioGRID; 213525; 1.
DR IntAct; Q8C3W1; 1.
DR MINT; Q8C3W1; -.
DR STRING; 10090.ENSMUSP00000034464; -.
DR iPTMnet; Q8C3W1; -.
DR PhosphoSitePlus; Q8C3W1; -.
DR EPD; Q8C3W1; -.
DR MaxQB; Q8C3W1; -.
DR PaxDb; Q8C3W1; -.
DR PeptideAtlas; Q8C3W1; -.
DR PRIDE; Q8C3W1; -.
DR Antibodypedia; 1577; 56 antibodies from 14 providers.
DR DNASU; 69551; -.
DR Ensembl; ENSMUST00000034464; ENSMUSP00000034464; ENSMUSG00000031983.
DR GeneID; 69551; -.
DR KEGG; mmu:69551; -.
DR UCSC; uc009nxg.1; mouse.
DR MGI; MGI:1916801; 2310022B05Rik.
DR VEuPathDB; HostDB:ENSMUSG00000031983; -.
DR eggNOG; ENOG502R926; Eukaryota.
DR GeneTree; ENSGT00390000018361; -.
DR HOGENOM; CLU_069832_0_0_1; -.
DR InParanoid; Q8C3W1; -.
DR OMA; TKSQMDF; -.
DR OrthoDB; 1581884at2759; -.
DR PhylomeDB; Q8C3W1; -.
DR TreeFam; TF334642; -.
DR BioGRID-ORCS; 69551; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8C3W1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8C3W1; protein.
DR Bgee; ENSMUSG00000031983; Expressed in otolith organ and 228 other tissues.
DR Genevisible; Q8C3W1; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR InterPro; IPR031600; DUF4706.
DR Pfam; PF15797; DUF4706; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9H425"
FT CHAIN 2..322
FT /note="Uncharacterized protein C1orf198 homolog"
FT /id="PRO_0000280343"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9H425"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H425"
FT MOD_RES 130
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 176
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H425"
FT CONFLICT 52
FT /note="E -> D (in Ref. 2; AAH58626)"
FT /evidence="ECO:0000305"
FT CONFLICT 78
FT /note="R -> H (in Ref. 1; BAE33133)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="D -> E (in Ref. 1; BAE32847)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 322 AA; 35316 MW; 2C0D2A472BE73284 CRC64;
MASMAAAIAA SRSAVMSGNR PLDDRERKRF TYFSSLSPMA RKIMQDKEKI REKYGPEWAR
LPPAQQDEII DRCLVGPRAP AAAADAGDVR DPARFPGLRG PTGQKLVRFG DEDITWQDEH
SAPFSWETRS QMEFSISSLS IQEPSAATVT SDARSLAKAP QGTQGSKPAQ SSRSSSLDAL
GPARKEEEAP FWKINAERSR EGPEAEFQSL TPSQIKSMEK GEKVLPACYR QEPTTKDREA
KPVPQEQQTL PSVSAEQEVP QPVQAPASLL PKATPTESPE KPPPPAVQRD EDDDALFSEP
ALAQISSSNV LLKTGFDFLD NW
