ID   CA1A1_CONLE             Reviewed;          43 AA.
AC   P0C901;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Alpha-conotoxin-like Leo-A1 {ECO:0000303|PubMed:18221274};
DE   Flags: Precursor;
OS   Conus leopardus (Leopard cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lithoconus.
OX   NCBI_TaxID=101306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=18221274; DOI=10.1111/j.1365-294x.2007.03627.x;
RA   Remigio E.A., Duda T.F. Jr.;
RT   "Evolution of ecological specialization and venom of a predatory marine
RT   gastropod.";
RL   Mol. Ecol. 17:1156-1162(2008).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By
CC       similarity). Has possibly a distinct nAChR binding mode from other
CC       alpha-conotoxins, due to a different three residue motif (lacks the
CC       Ser-Xaa-Pro motif) (By similarity). {ECO:0000250|UniProtKB:Q2I2R8}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18221274}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:18221274}.
CC   -!- DOMAIN: The cysteine framework is I (CC-C-C). Alpha4/7 pattern.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF467320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0C901; -.
DR   TCDB; 8.B.32.1.8; the nicotinic acetylcholine receptor-targeting alpha-conotoxin (a-conotoxin) family.
DR   ConoServer; 3724; Lp1.11 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   3: Inferred from homology;
KW   Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Toxin.
FT   PROPEP          1..26
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000368001"
FT   PEPTIDE         26..43
FT                   /note="Alpha-conotoxin-like Leo-A1"
FT                   /evidence="ECO:0000250|UniProtKB:X1WB75"
FT                   /id="PRO_0000368002"
FT   REGION          30..32
FT                   /note="Lacks the Ser-Xaa-Pro motif that is crucial for
FT                   potent interaction with nAChR"
FT                   /evidence="ECO:0000305"
FT   DISULFID        28..34
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
FT   DISULFID        29..42
FT                   /evidence="ECO:0000250|UniProtKB:P56636"
SQ   SEQUENCE   43 AA;  4461 MW;  79169990DF8DE57E CRC64;
     LTLDRASDDT DVAAEIMSGL IALAIDSCCS DSDCNANHPD MCS