CA1AA_XENLA
ID CA1AA_XENLA Reviewed; 896 AA.
AC Q98TA5;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Chromatin assembly factor 1 subunit A-A;
DE Short=CAF-1 subunit A;
DE AltName: Full=Chromatin assembly factor I p150 subunit A;
DE Short=CAF-I 150 kDa subunit A;
DE Short=CAF-I p150-A;
DE Short=xp150;
GN Name=chaf1a-a; Synonyms=caip150;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, HOMODIMER, AND SUBCELLULAR LOCATION.
RX PubMed=11296234; DOI=10.1093/emboj/20.8.2015;
RA Quivy J.-P., Grandi P., Almouzni G.;
RT "Dimerization of the largest subunit of chromatin assembly factor 1:
RT importance in vitro and during Xenopus early development.";
RL EMBO J. 20:2015-2027(2001).
CC -!- FUNCTION: Involved in chromatin assembly in DNA replication and DNA
CC repair. {ECO:0000250, ECO:0000269|PubMed:11296234}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- INTERACTION:
CC Q98TA5; Q7ZZH7: dbf4; NbExp=2; IntAct=EBI-8563970, EBI-8563988;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11296234}.
CC -!- SIMILARITY: Belongs to the CHAF1A family. {ECO:0000305}.
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DR EMBL; AF222339; AAK31811.1; -; mRNA.
DR RefSeq; NP_001082096.1; NM_001088627.1.
DR AlphaFoldDB; Q98TA5; -.
DR IntAct; Q98TA5; 1.
DR MINT; Q98TA5; -.
DR PRIDE; Q98TA5; -.
DR GeneID; 398222; -.
DR KEGG; xla:398222; -.
DR CTD; 398222; -.
DR Xenbase; XB-GENE-17342845; chaf1a.L.
DR OrthoDB; 1362011at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 398222; Expressed in blastula and 19 other tissues.
DR GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IMP:UniProtKB.
DR InterPro; IPR029105; CAF1-p150_C2.
DR InterPro; IPR029091; CAF1_p150_N.
DR InterPro; IPR022043; CAF1A.
DR Pfam; PF15539; CAF1-p150_C2; 1.
DR Pfam; PF15557; CAF1-p150_N; 1.
DR Pfam; PF12253; CAF1A; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Chaperone; DNA damage; DNA repair; DNA replication; Nucleus;
KW Reference proteome.
FT CHAIN 1..896
FT /note="Chromatin assembly factor 1 subunit A-A"
FT /id="PRO_0000373884"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..678
FT /note="Necessary for homodimerization, competence for
FT chromatin assembly"
FT REGION 724..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 101067 MW; 8A4F0FABA3CA0783 CRC64;
MPGKEAAVNV MQSSTKSNTK KMVQARLPFK RLNPVPKDEG CLEEKKVRIT KNVSPQKMLH
SLNSSMEDME NDCDMETETV PIPKAVNGKG PLDNYIRKAP KVSHAPSITT IDLTEESNIS
ISNDCPLNGE SETHLANGTL ALEESTPNLP LSAKEECTVS LENKTVENTH FSELKSDQLH
QAAATSTSAS NFSPERVVKE DCNSSADDDS ASVSSSSSPV SLSSPDAQTG SQFRNRSSPS
TSTTPTGKVT ANKTSADKNK TKDKDKQRQA EKEERERAKK EARSAKKKKR QGLLKNLQRK
RGKTSESSGK EYKKEKKERE DKEKAEKMKL KEEKKREKLE ALEAKQEEKR KKDEEKRQKE
EEKRQKEEEK RLKEEEKRVK AEKAEITRFF QKPKTPQAPK TFSRSCGKFA PFEIKKGMAL
APLCRIDFEP EASEELDRFL QEQNSKIYFF DEIKKRKPRK MGQTTVPTVN SFEVDDVQVL
GESDPVLGSN MLEGHIKDIG VPERKKFGRM KLLQFCENHR PAYWGTCNRR SRVINSRKPW
AQDTGMLDYE VDSDEEWEEE EPGESLSHSE GENDDDPKED DEDDDGFFVP HGYLSDDEGV
SDEECTDPEN QKFRQKLKAK EWYELQTNGK KIRAMQPVVI GCVWWDSKAS EISLLQKFSA
CILESPAVDE ELAQEISSAQ SLKDRQILSK LVPLLHGNVN GSKIMIQEFQ EYCRRGLFLE
DNASDAAGNE STSPNVTPQT PSNIIVPSKA RLKRLISENS VYEKRPDHRM CWYVHSDVLK
GLQQDNLPVP CQWTYITQVN SVAKEDNGAN GGSLQSLPLS GKRKSAGSMP ITKFMKRAKD
LETAINTDMD GFQADNEEDD DDCMILEDQQ AKDAEDSTIE CKINLNDSAV LASCQN
