ID   CA1AB_XENLA             Reviewed;         885 AA.
AC   A0JMT0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Chromatin assembly factor 1 subunit A-B;
DE            Short=CAF-1 subunit A;
DE   AltName: Full=Chromatin assembly factor I p150 subunit B;
DE            Short=CAF-I 150 kDa subunit B;
DE            Short=CAF-I p150-B;
DE            Short=xp150;
GN   Name=chaf1a-b; Synonyms=caip150;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in chromatin assembly in DNA replication and DNA
CC       repair. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CHAF1A family. {ECO:0000305}.
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DR   EMBL; BC125993; AAI25994.1; -; mRNA.
DR   RefSeq; NP_001089089.1; NM_001095620.1.
DR   RefSeq; XP_018094603.1; XM_018239114.1.
DR   AlphaFoldDB; A0JMT0; -.
DR   BioGRID; 591746; 4.
DR   GeneID; 733264; -.
DR   KEGG; xla:733264; -.
DR   CTD; 733264; -.
DR   Xenbase; XB-GENE-1001158; chaf1a.S.
DR   OMA; MENDCEM; -.
DR   OrthoDB; 1362011at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 733264; Expressed in blastula and 18 other tissues.
DR   GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR029105; CAF1-p150_C2.
DR   InterPro; IPR029091; CAF1_p150_N.
DR   InterPro; IPR022043; CAF1A.
DR   Pfam; PF15539; CAF1-p150_C2; 1.
DR   Pfam; PF15557; CAF1-p150_N; 1.
DR   Pfam; PF12253; CAF1A; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Chaperone; Coiled coil; DNA damage; DNA repair;
KW   DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..885
FT                   /note="Chromatin assembly factor 1 subunit A-B"
FT                   /id="PRO_0000373885"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..361
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..605
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          629..665
FT                   /note="Necessary for homodimerization, competence for
FT                   chromatin assembly"
FT                   /evidence="ECO:0000250"
FT   COILED          251..376
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        181..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..361
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..573
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  99669 MW;  D065CEED8ACDD678 CRC64;
     MPGKEAAGDV MKSSTKSNTK KMVQARLPFK RLNPVPKDEG CLEEKKIRIP QNVSPQKMLY
     SLNSSMEDME NDCEMETEMT PIPKAINGKG PLDNYIRKAP KASNAPSIIT IDLTEDSNIS
     TSNDSPLNGE SRAQLANGTV SPERSTTNAP LSTNEECTVS VDNKSLENMS FPELELDKPH
     QSAASCTSVS NFSPERAVKE DYNSSADDDS VSVSSSSSPV SLSSPDVQTG SKFTNGSSPS
     TSTTPTGKAT SNKTSAEKKK TKDKAEKRQA EKEERECARR EARAAKDLAK KKREGEREQR
     EKDKKEKKER EDREKAEKNR LKEEKKKEKL EALEAKQEEK RKKEEEKRQK EEEKRLKEEE
     KRIKAEKAEI TRFLQKPKTP QAPKTFARSC GKFAPFEIKK GMALAPLCRI DFEQEASEEL
     DIFLQEQTSE SSFLDEIKKR RPRKMGQTTV PTINSVEVDD VQVLGETDPV LGSNMVLEEH
     IKDIGVPERK KFGRMKLLQF CENHRPAYWG TSNKRSRVIN PRKPWAQDTD MLDYEVDSDE
     EWEEEEPGES LSHSEGENED DDPKEEEDED DDGFFVPHGY LSNDEGVSDE ECTDPENQKV
     RQKLKAKEWD DLQSNSKKIR VLQPVVIGCV WCDSKASEIR LLQKFSACIL ESPAVEEELT
     QDISSAQKIK DRQILSKLVP LLHGNVNGSK IIIQEFQECC RRGLFLEDNA SHATDIESTS
     PNSTPQTPSN IIVPSKARLK RLISENSVYE KRPEHRMCWY VHSDVLKGLQ QDNLPVPCQW
     TYITQVNSVS KENNGANGGS LQSLPLSGKR KSAGSMPITK FMKRARDLET AVNTDMDGFQ
     ADTEEEEDDD DCMIIEDQQA KDAEDSTIEC KINLNDSAIL ASCQN