ULI1_YEAST
ID ULI1_YEAST Reviewed; 169 AA.
AC P43604; D6VTQ6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Unfolded protein response-inducible protein 1;
DE Short=UPR-L-inducible protein 1;
GN Name=ULI1; OrderedLocusNames=YFR026C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8686381;
RX DOI=10.1002/(sici)1097-0061(199602)12:2<177::aid-yea896>3.0.co;2-a;
RA Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M.,
RA Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H.,
RA Hanaoka F., Murakami Y.;
RT "Fifteen open reading frames in a 30.8 kb region of the right arm of
RT chromosome VI from Saccharomyces cerevisiae.";
RL Yeast 12:177-190(1996).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP FUNCTION, AND INDUCTION.
RX PubMed=19073890; DOI=10.1091/mbc.e08-02-0140;
RA Metzger M.B., Michaelis S.;
RT "Analysis of quality control substrates in distinct cellular compartments
RT reveals a unique role for Rpn4p in tolerating misfolded membrane
RT proteins.";
RL Mol. Biol. Cell 20:1006-1019(2009).
CC -!- FUNCTION: Involved in the unfolded protein response (UPR), a
CC transcriptional response which up-regulates genes that enable cells to
CC cope with misfolded, endoplasmic reticulum-retained proteins. UPR is
CC part of the endoplasmic reticulum quality control (ERQC) which prevents
CC the exit of misfolded secretory and membrane proteins from the
CC endoplasmic reticulum. {ECO:0000269|PubMed:19073890}.
CC -!- INDUCTION: By the unfolded protein response (UPR).
CC {ECO:0000269|PubMed:19073890}.
CC -!- MISCELLANEOUS: Present with 721 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; D50617; BAA09265.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12466.1; -; Genomic_DNA.
DR PIR; S56281; S56281.
DR RefSeq; NP_116682.3; NM_001179991.3.
DR AlphaFoldDB; P43604; -.
DR BioGRID; 31180; 21.
DR DIP; DIP-2811N; -.
DR IntAct; P43604; 1.
DR STRING; 4932.YFR026C; -.
DR PaxDb; P43604; -.
DR PRIDE; P43604; -.
DR EnsemblFungi; YFR026C_mRNA; YFR026C; YFR026C.
DR GeneID; 850583; -.
DR KEGG; sce:YFR026C; -.
DR SGD; S000001922; ULI1.
DR VEuPathDB; FungiDB:YFR026C; -.
DR HOGENOM; CLU_1579731_0_0_1; -.
DR OMA; NNSCVAF; -.
DR BioCyc; YEAST:G3O-30475-MON; -.
DR PRO; PR:P43604; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43604; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:SGD.
PE 1: Evidence at protein level;
KW Reference proteome; Unfolded protein response.
FT CHAIN 1..169
FT /note="Unfolded protein response-inducible protein 1"
FT /id="PRO_0000202692"
SQ SEQUENCE 169 AA; 18809 MW; BB1F4943C9A6815F CRC64;
MTPYAVAITV ALLIVTVSAL QVNNSCVAFP PSNLRGKNGD GTNEQYATAL LSIPWNGPPE
SLRDINLIEL EPQVALYLLE NYINHYYNTT RDNKCPNNHY LMGGQLGSSS DNRSLNDPQT
MLWPEKKEDE KNCQETFKGA CSCTKRFCKG YFSVNIFGIN LNISYSSGK
