ULT1_ARATH
ID ULT1_ARATH Reviewed; 237 AA.
AC Q8GZA8; Q8L8S8; Q9M0I8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein ULTRAPETALA 1 {ECO:0000303|PubMed:15673576};
GN Name=ULT1 {ECO:0000303|PubMed:15673576};
GN OrderedLocusNames=At4g28190 {ECO:0000312|Araport:AT4G28190};
GN ORFNames=F26K10.70 {ECO:0000312|EMBL:CAB79621.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND MUTAGENESIS OF SER-83 AND CYS-173.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=15673576; DOI=10.1242/dev.01642;
RA Carles C.C., Choffnes-Inada D., Reville K., Lertpiriyapong K.,
RA Fletcher J.C.;
RT "ULTRAPETALA1 encodes a SAND domain putative transcriptional regulator that
RT controls shoot and floral meristem activity in Arabidopsis.";
RL Development 132:897-911(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND IDENTIFICATION.
RX PubMed=15342527; DOI=10.1534/genetics.104.028787;
RA Carles C.C., Lertpiriyapong K., Reville K., Fletcher J.C.;
RT "The ULTRAPETALA1 gene functions early in Arabidopsis development to
RT restrict shoot apical meristem activity and acts through WUSCHEL to
RT regulate floral meristem determinacy.";
RL Genetics 167:1893-1903(2004).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=18441215; DOI=10.1105/tpc.107.053306;
RA Prunet N., Morel P., Thierry A.-M., Eshed Y., Bowman J.L., Negrutiu I.,
RA Trehin C.;
RT "REBELOTE, SQUINT, and ULTRAPETALA1 function redundantly in the temporal
RT regulation of floral meristem termination in Arabidopsis thaliana.";
RL Plant Cell 20:901-919(2008).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH ATX1.
RC STRAIN=cv. Columbia;
RX PubMed=23632855; DOI=10.1104/pp.112.213223;
RA Pu L., Liu M.-S., Kim S.Y., Chen L.-F.O., Fletcher J.C., Sung Z.R.;
RT "EMBRYONIC FLOWER1 and ULTRAPETALA1 Act Antagonistically on Arabidopsis
RT Development and Stress Response.";
RL Plant Physiol. 162:812-830(2013).
RN [9]
RP INTERACTION WITH HHO5.
RX PubMed=26903506; DOI=10.1242/dev.127365;
RA Moreau F., Thevenon E., Blanvillain R., Lopez-Vidriero I.,
RA Franco-Zorrilla J.M., Dumas R., Parcy F., Morel P., Trehin C., Carles C.C.;
RT "The Myb-domain protein ULTRAPETALA1 INTERACTING FACTOR 1 controls floral
RT meristem activities in Arabidopsis.";
RL Development 143:1108-1119(2016).
CC -!- FUNCTION: Putative transcription factor that acts as a key negative
CC regulator of cell accumulation in shoot and floral meristems.
CC Negatively regulates the size of the WUSCHEL (WUS)-expressing
CC organizing center in inflorescence meristems. May act by down-
CC regulating expression of WUS. Acts as an antirepressor that counteracts
CC EMF1 action through modulation of trimethylated 'Lys-4' on histone H3
CC (H3K4me3) marks on target gene loci (including genes involved in salt
CC stress response and flower development) (PubMed:23632855).
CC Collaboratively with RBL and CYP40/SQN, influences floral meristem (FM)
CC determinacy in an AGAMOUS and SUPERMAN-dependent manner, thus
CC contributing to the floral developmental homeostasis (PubMed:18441215).
CC {ECO:0000269|PubMed:15342527, ECO:0000269|PubMed:15673576,
CC ECO:0000269|PubMed:18441215, ECO:0000269|PubMed:23632855}.
CC -!- SUBUNIT: Interacts with HHO5 (PubMed:26903506). Associates with ATX1
CC for trimethylating 'Lys-4' on histone H3 (H3K4me3) at flower MADS box
CC gene loci (PubMed:23632855). {ECO:0000269|PubMed:23632855,
CC ECO:0000269|PubMed:26903506}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15673576}. Nucleus
CC {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000269|PubMed:15673576}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8GZA8-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in seedlings, roots,
CC shoots, leaves, stems, inflorescences, pollen, flowers and siliques,
CC with highest levels dividing tissues including inflorescence.
CC {ECO:0000269|PubMed:15673576, ECO:0000269|PubMed:18441215}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryonic shoot apical meristems, in
CC inflorescence and floral meristems, and in developing stamens, carpels
CC and ovules. Also expressed in vegetative meristems and leaf primordia.
CC {ECO:0000269|PubMed:15673576}.
CC -!- DISRUPTION PHENOTYPE: Delayed flowering and higher floral organs number
CC with extra petals and sepals (PubMed:23632855). Increased H3K27me3
CC marks but decreased H3K4me3 marks on target gene loci
CC (PubMed:23632855). Plants missing both EMF1 and ULT1 have rescued
CC normal H3K27me3 marks and H3K4me3 marks (PubMed:23632855). Plants
CC lacking both CRC and ULT1 exhibit strong floral meristem (FM)
CC indeterminacy with reiterations of extra floral whorls in the center of
CC the flower associated with reduced AGAMOUS and SUPERMAN levels
CC (PubMed:18441215). {ECO:0000269|PubMed:18441215,
CC ECO:0000269|PubMed:23632855}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM67142.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB79621.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL161572; CAB79621.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85451.1; -; Genomic_DNA.
DR EMBL; AK117106; BAC41785.1; -; mRNA.
DR EMBL; AY088835; AAM67142.1; ALT_INIT; mRNA.
DR PIR; T09035; T09035.
DR RefSeq; NP_567799.1; NM_118959.5. [Q8GZA8-1]
DR AlphaFoldDB; Q8GZA8; -.
DR BioGRID; 14221; 10.
DR IntAct; Q8GZA8; 5.
DR PRIDE; Q8GZA8; -.
DR ProteomicsDB; 245311; -. [Q8GZA8-1]
DR EnsemblPlants; AT4G28190.1; AT4G28190.1; AT4G28190. [Q8GZA8-1]
DR GeneID; 828934; -.
DR Gramene; AT4G28190.1; AT4G28190.1; AT4G28190. [Q8GZA8-1]
DR KEGG; ath:AT4G28190; -.
DR Araport; AT4G28190; -.
DR HOGENOM; CLU_100373_0_0_1; -.
DR InParanoid; Q8GZA8; -.
DR PhylomeDB; Q8GZA8; -.
DR PRO; PR:Q8GZA8; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8GZA8; baseline and differential.
DR Genevisible; Q8GZA8; AT.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009910; P:negative regulation of flower development; IMP:UniProtKB.
DR GO; GO:0009909; P:regulation of flower development; IMP:UniProtKB.
DR GO; GO:1905435; P:regulation of histone H3-K4 trimethylation; IMP:UniProtKB.
DR GO; GO:1901000; P:regulation of response to salt stress; IMP:UniProtKB.
DR Gene3D; 3.10.390.10; -; 1.
DR InterPro; IPR020533; Developmental_reg_ULTRAPETALA.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR000770; SAND_dom.
DR PANTHER; PTHR34053; PTHR34053; 1.
DR PROSITE; PS50864; SAND; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; DNA-binding;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..237
FT /note="Protein ULTRAPETALA 1"
FT /id="PRO_0000074103"
FT DOMAIN 18..116
FT /note="SAND"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00185"
FT ZN_FING 133..191
FT /note="CW-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00454"
FT MUTAGEN 83
FT /note="S->F: In ult1-1; induces enlargement of
FT inflorescence and floral meristems, production of
FT supernumerary flowers and floral organs, and a delay in
FT floral meristem termination."
FT /evidence="ECO:0000269|PubMed:15673576"
FT MUTAGEN 173
FT /note="C->T: In ult1-1; semi-dominant allele that induces
FT enlargement of inflorescence and floral meristems,
FT production of supernumerary flowers and floral organs, and
FT a delay in floral meristem termination."
FT /evidence="ECO:0000269|PubMed:15673576"
FT CONFLICT 103
FT /note="K -> N (in Ref. 5; AAM67142)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 237 AA; 26744 MW; ED22FA1696BF1D81 CRC64;
MANNEGEMQC GSMLFKQEEL QEMSGVNVGG DYVEVMCGCT SHRYGDAVAR LRVFPTGDLE
ITCECTPGCD EDKLTPAAFE KHSGRETARK WKNNVWVIIG GEKVPLSKTV LLKYYNESSK
KCSRSNRSQG AKVCHRDEFV GCNDCGKERR FRLRSRDECR LHHNAMGDPN WKCSDFPYDK
ITCEEEEERG SRKVYRGCTR SPSCKGCTSC VCFGCELCRF SECTCQTCVD FTSNVKA
