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UMPB_HALZH
ID   UMPB_HALZH              Reviewed;         271 AA.
AC   A0A1X9QDU5;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Na(+), Li(+), K(+)/H(+) antiporter subunit B {ECO:0000305};
DE   AltName: Full=Na(+) (Li(+)/K(+))/H(+) antiporter subunit B {ECO:0000305};
GN   Name=umpB {ECO:0000303|PubMed:28652569};
OS   Halomonas zhaodongensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1176240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES,
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RC   STRAIN=DSM 25869 / NEAU-ST10-25;
RX   PubMed=28652569; DOI=10.1038/s41598-017-04236-0;
RA   Meng L., Meng F., Zhang R., Zhang Z., Dong P., Sun K., Chen J., Zhang W.,
RA   Yan M., Li J., Abdel-Motaal H., Jiang J.;
RT   "Characterization of a novel two-component Na+(Li+, K+)/H+ antiporter from
RT   Halomonas zhaodongensis.";
RL   Sci. Rep. 7:4221-4221(2017).
CC   -!- FUNCTION: Part of a two-component antiporter that catalyzes the efflux
CC       of Na(+), Li(+) and K(+) in exchange for external protons. Shows a
CC       preference for Na(+), followed by K(+) and Li(+).
CC       {ECO:0000269|PubMed:28652569}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 9.0. Exhibits antiport activity at a wide pH range of
CC         6.5 to 9.5. {ECO:0000269|PubMed:28652569};
CC   -!- SUBUNIT: Heterodimer composed of UmpA and UmpB.
CC       {ECO:0000269|PubMed:28652569}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:28652569};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the UmpA/UmpB family. {ECO:0000305}.
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DR   EMBL; KY241440; ARQ20735.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X9QDU5; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR011435; UmpAB.
DR   Pfam; PF07556; DUF1538; 1.
PE   1: Evidence at protein level;
KW   Antiport; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..271
FT                   /note="Na(+), Li(+), K(+)/H(+) antiporter subunit B"
FT                   /id="PRO_0000446279"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          252..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  29561 MW;  FA89787D810997A5 CRC64;
     MILLTIFWDT LLDILPIAAI IFGFQYIVIR KRIQRLPQVL AGFFMVWVGL SLFLVGLEQA
     LFPMGELMAS QLTNTDFLPA VEQGVQRHWA DYYWVYLFAF AIGASTTIAE PSLIAVSIKA
     GEISGGTINP FMLRIAVALG MAFGITLGTW RIVMGWPLQW FVFAAYCLVI IQTLRSPKSI
     IPLAFDSGGV TTSTITVPII AALGLGLAAS IPGRSALMDG FGMIALACLF PIITVMGYAQ
     IAQWKDKRKQ TTPHLSYSKA PPPSKGDNNA L
 
 
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