ID   UMUC_SALTY              Reviewed;         422 AA.
AC   P22494;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Protein UmuC;
GN   Name=umuC; OrderedLocusNames=STM1997;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2144275; DOI=10.1128/jb.172.9.4964-4978.1990;
RA   Smith C.M., Koch W.H., Franklin S.B., Foster P.L., Cebula T.A.,
RA   Eisenstadt E.;
RT   "Sequence analysis and mapping of the Salmonella typhimurium LT2 umuDC
RT   operon.";
RL   J. Bacteriol. 172:4964-4978(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=2203737; DOI=10.1128/jb.172.9.4979-4987.1990;
RA   Thomas S.M., Crowne H.M., Pidsley S.C., Sedgwick S.G.;
RT   "Structural characterization of the Salmonella typhimurium LT2 umu
RT   operon.";
RL   J. Bacteriol. 172:4979-4987(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Involved in UV protection and mutation. Essential for induced
CC       (or SOS) mutagenesis. May modify the DNA replication machinery to allow
CC       bypass synthesis across a damaged template.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family. {ECO:0000305}.
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DR   EMBL; M57431; AAA27248.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20907.1; -; Genomic_DNA.
DR   PIR; B36713; B36713.
DR   RefSeq; NP_460948.1; NC_003197.2.
DR   RefSeq; WP_000457662.1; NC_003197.2.
DR   AlphaFoldDB; P22494; -.
DR   SMR; P22494; -.
DR   STRING; 99287.STM1997; -.
DR   PaxDb; P22494; -.
DR   EnsemblBacteria; AAL20907; AAL20907; STM1997.
DR   GeneID; 1253518; -.
DR   KEGG; stm:STM1997; -.
DR   PATRIC; fig|99287.12.peg.2115; -.
DR   HOGENOM; CLU_012348_3_0_6; -.
DR   OMA; YRYEPHR; -.
DR   PhylomeDB; P22494; -.
DR   BioCyc; SENT99287:STM1997-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR   GO; GO:0009432; P:SOS response; IBA:GO_Central.
DR   Gene3D; 3.30.1490.100; -; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR025188; DUF4113.
DR   InterPro; IPR024728; PolY_HhH_motif.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   Pfam; PF13438; DUF4113; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   Pfam; PF11798; IMS_HHH; 1.
DR   SUPFAM; SSF100879; SSF100879; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome; SOS mutagenesis; SOS response.
FT   CHAIN           1..422
FT                   /note="Protein UmuC"
FT                   /id="PRO_0000173983"
FT   DOMAIN          2..188
FT                   /note="UmuC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00216"
SQ   SEQUENCE   422 AA;  47728 MW;  2124066C7264FE65 CRC64;
     MFALCDVNSF YASCETVFRP DLCGRPVVVL SNNDGCVIAC SAEAKQLGIA PGEPYFKQKE
     RFRRSGVVCF SSNYELYADM SNRVMTTLEE MVPRVEIYSI DEAFCDLTGV RNCRDLTDFG
     REIRATVLKR THLTVGVGIA QTKTLAKLAN HAAKKWQRQT DGVVDLSNID RQRRLLALIP
     VEDVWGVGRR ISKKLNALGI KTALDLSEQS TWIIRKHFNV VLERTVRELR GEPCLELEEF
     APAKQEIVCS RSFGERVTDY EEMRQAVYSY AARAAEKLRG EHQYCRFIST FVKTSPFALN
     EPYYGNSAAV TLLTPTQDSR DIINAAVKCL DKIWRDGHRY QKAGVMLGDF FSQGVAQLNL
     FDDNAPRAGS AKLMEVLDHL NAKDGKGTLY FAGQGMSQQW AMKREMLSPR YTTRYSDLLR
     VK